Fisetin (senolytic potential)? @TheSheekeyScienceShow

Uploaded January 2021 | Updated September 2026, 2 weeks ago

Finally talking about fisetin. Does it activate SIR1? Does it have senolytic potential? Is it safe? What is the bioavailability? Clinical trials? How does it compare it to quercetin? What even is senscence? Don't worry, i've got you covered. Watch on for more :DD

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TIMESTAMPS
Intro - 00:00
Fisetin - 00:18
Senolytic potential - 02:30
Clinical trials - 08:30
Is it safe? - 10:26

References;
Senotherapeutic - DOI:doi.org/10.1016/j.ebiom.2018.09.015
and check out @LifespanIO journal club!!
Howitz, K., Bitterman, K., Cohen, H. et al. Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Nature 425, 191–196 (2003). doi.org/10.1038/nature01960
Senolytic drugs review doi.org/10.1111/joim.13141
Fisetin acts on multiple pathways - Front Biosci (Schol Ed). 2015 Jun 1; 7: 58–82.

Icons in intro; "freepik.com/free-photos-vectors/background"Background vector created by freepik - freepik.com

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$Follistatin - why is this the new longevity trend? Muscle loss, also known as sarcopenia, is a natural part of aging that occurs due to various factors, such as reduced physical activity, hormonal changes, and protein deficiency. Muscle loss can lead to weakness, mobility problems, falls, fractures, and increased risk of chronic diseases. There are also various genetic diseases that result in muscle loss and reduced function and hence much research has been conducted to find therapeutic solutions focusing on myostatin and follistatin. Well take a look at a mouse study that saw longevity benefits following follistatin gene therapy and some clinical trials in development. Find me on Twitter - https://twitter.com/EleanorSheekey Support the channel through PayPal - https://paypal.me/sheekeyscience?country.x=GB&locale.x=en_GB through Patreon - https://www.patreon.com/TheSheekeyScienceShow TIMESTAMPS Intro - 00:00 Myostatin - 00:55 Follistatin - 02:11 References: McPherron, A., Lawler, A. & Lee, SJ. Regulation of skeletal muscle mass in mice by a new TGF-p superfamily member. *Nature* **387**, 83–90 (1997). https://doi-org.ezp.lib.cam.ac.uk/10.1038/387083a0 New intranasal and injectable gene therapy for healthy life extension - https://doi.org/10.1073/pnas.2121499119 Follistatin-induced muscle hypertrophy in aged mice improves neuromuscular junction innervation and function - https://doi.org/10.1016/j.neurobiolaging.2021.03.005 Follistatin Gene Delivery Enhances Muscle Growth and Strength in Nonhuman Primates - https://doi.org/10.1126/scitranslmed.3000112 Please note that The Sheekey Science Show is distinct from Eleanor Sheekeys teaching and research roles at the University of Cambridge. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Sheekey Science Show and guests assume no liability for the application of the information discussed.$