How to deliver CRISPR machinery in patients? (in vivo approaches)

Uploaded September 2021 | Updated September 2026, 2 weeks ago

This is part of my interview with Prof David Liu - youtu.be/ml1svbRo7Lg

Here we discuss how to deliver CRISPR machinery in patients (in vivo approaches) such as via lipid nanoparticles or adeno-associated viruses.

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I have Patreon - patreon.com/TheSheekeyScienceShow

How to deliver CRISPR machinery in patients? (in vivo approaches) | Prof David Liu

$Follistatin - why is this the new longevity trend? Muscle loss, also known as sarcopenia, is a natural part of aging that occurs due to various factors, such as reduced physical activity, hormonal changes, and protein deficiency. Muscle loss can lead to weakness, mobility problems, falls, fractures, and increased risk of chronic diseases. There are also various genetic diseases that result in muscle loss and reduced function and hence much research has been conducted to find therapeutic solutions focusing on myostatin and follistatin. Well take a look at a mouse study that saw longevity benefits following follistatin gene therapy and some clinical trials in development. Find me on Twitter - https://twitter.com/EleanorSheekey Support the channel through PayPal - https://paypal.me/sheekeyscience?country.x=GB&locale.x=en_GB through Patreon - https://www.patreon.com/TheSheekeyScienceShow TIMESTAMPS Intro - 00:00 Myostatin - 00:55 Follistatin - 02:11 References: McPherron, A., Lawler, A. & Lee, SJ. Regulation of skeletal muscle mass in mice by a new TGF-p superfamily member. *Nature* **387**, 83–90 (1997). https://doi-org.ezp.lib.cam.ac.uk/10.1038/387083a0 New intranasal and injectable gene therapy for healthy life extension - https://doi.org/10.1073/pnas.2121499119 Follistatin-induced muscle hypertrophy in aged mice improves neuromuscular junction innervation and function - https://doi.org/10.1016/j.neurobiolaging.2021.03.005 Follistatin Gene Delivery Enhances Muscle Growth and Strength in Nonhuman Primates - https://doi.org/10.1126/scitranslmed.3000112 Please note that The Sheekey Science Show is distinct from Eleanor Sheekeys teaching and research roles at the University of Cambridge. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Sheekey Science Show and guests assume no liability for the application of the information discussed.$

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$Reproducing Rejuvenation: Inside the Pig Plasma Longevity Experiments Could pig plasma fractions really rejuvenate aging rats? Join me as I interview Nicolás and Nina from the Rejuvenation Science Institute (Brazil), who are working to reproduce the headline-creating “pig plasma rejuvenation” results. We explore the origins, science, controversies, challenges, and hopes surrounding this research—plus their plans for the next breakthrough longevity experiment and open science collaboration. https://www.rejuvenescimento.org/english https://www.rejuvenescimento.org/newsletter https://journals.tmkarpinski.com/index.php/ejbr/article/view/772 Timestamps 00:00 – Introduction: The Pig Plasma Rat Rejuvenation Debate 02:00 – Origins: Why try to reproduce these results? 08:30 – What is being injected? Fraction preparation explained 15:40 – Acute toxicity and safety results: did the rats survive? 26:00 – The next experiment: timelines, scale-up, and open science goals Find me on Twitter - https://twitter.com/EleanorSheekey Support the channel through PayPal - https://paypal.me/sheekeyscience?country.x=GB&locale.x=en_GB through Patreon - https://www.patreon.com/TheSheekeyScienceShow Please note that The Sheekey Science Show is distinct from Eleanor Sheekeys teaching and research roles. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Sheekey Science Show and guests assume no liability for the application of the information discussed. Icons in intro; https://www.freepik.com/free-photos-vectors/backgroundBackground vector created by freepik - www.freepik.com$

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