Uploaded May 2026 | Updated September 2026, 1 week ago
Link: open.substack.com/pub/staycuriousmetabolism/p/will-this-gene-editing-breakthrough?r=40ekz2&utm_medium=ios
The headline-breaking news this week was that scientists are now gene editing humans to lower LDL.
People are calling it one of the biggest cardiology breakthroughs of the century.
But people are missing the bigger story. What’s truly fascinating is the technology itself.
This therapy uses CRISPR gene editing packaged inside a lipid nanoparticle engineered with a molecular targeting signal that direct it specifically to the liver.
Not the brain.
Not the heart.
Not muscle.
Not fat tissue.
Just the liver.
That level of precision opens the door to something much larger than cholesterol lowering. Because once you can safely and selectively edit specific tissues, you we open to door to preventing a host of chronic diseases, from obesity to diabetes to Alzheimer’s to autoimmune diseases … and you’re potentially talking about upgrading aspects of the human operating system itself.
Now, there are still major hurdles ahead, which we discuss in the letter.
But this is a very interesting first step. It’s not a cholesterol story — that’s just the proverbial click bait.
#LDL #APOB #STAYCURIOUS #PCSK9 #CRISPR #VERVE102
Link: open.substack.com/pub/staycuriousmetabolism/p/will-this-gene-editing-breakthrough?r=40ekz2&utm_medium=ios
The headline-breaking news this week was that scientists are now gene editing humans to lower LDL.
People are calling it one of the biggest cardiology breakthroughs of the century.
But people are missing the bigger story. What’s truly fascinating is the technology itself.
This therapy uses CRISPR gene editing packaged inside a lipid nanoparticle engineered with a molecular targeting signal that direct it specifically to the liver.
Not the brain.
Not the heart.
Not muscle.
Not fat tissue.
Just the liver.
That level of precision opens the door to something much larger than cholesterol lowering. Because once you can safely and selectively edit specific tissues, you we open to door to preventing a host of chronic diseases, from obesity to diabetes to Alzheimer’s to autoimmune diseases … and you’re potentially talking about upgrading aspects of the human operating system itself.
Now, there are still major hurdles ahead, which we discuss in the letter.
But this is a very interesting first step. It’s not a cholesterol story — that’s just the proverbial click bait.
#LDL #APOB #STAYCURIOUS #PCSK9 #CRISPR #VERVE102
