Uploaded July 2026 | Updated September 2026, 1 week ago
Deep Dive Letter: staycuriousmetabolism.substack.com/p/what-happens-to-your-body-during?r=40ekz2
Most people stop a fast just before the benefits kick in.
A study published in Nature Metabolism (PMID: 38429390) followed 12 healthy people who completed a 7-day, water-only fast. The researchers tracked approximately 3,000 proteins and discovered a massive biological shift that occurred around day three.
This shift resembled a software update for the body, with changes in the expression of more than 1,000 proteins linked to pathways involved in longevity, cardiovascular health, and brain health. Even more interesting, there may be ways to accelerate these biological changes so they begin before the 72-hour mark.
For the full deep dive—including the science, caveats, and practical strategies—check out the deep dive linked above.
#fasting #longevity #metabolism #staycurious #nicknorwitz
Deep Dive Letter: staycuriousmetabolism.substack.com/p/what-happens-to-your-body-during?r=40ekz2
Most people stop a fast just before the benefits kick in.
A study published in Nature Metabolism (PMID: 38429390) followed 12 healthy people who completed a 7-day, water-only fast. The researchers tracked approximately 3,000 proteins and discovered a massive biological shift that occurred around day three.
This shift resembled a software update for the body, with changes in the expression of more than 1,000 proteins linked to pathways involved in longevity, cardiovascular health, and brain health. Even more interesting, there may be ways to accelerate these biological changes so they begin before the 72-hour mark.
For the full deep dive—including the science, caveats, and practical strategies—check out the deep dive linked above.
#fasting #longevity #metabolism #staycurious #nicknorwitz
