Uploaded August 2026 | Updated September 2026, 2 weeks ago
This week I'm joined by Dr Jack Kreindler, physician, healthtech entrepreneur and founder of WellFounded Health, and someone who has spent 26 years asking one of the most important questions in medicine, what does it mean to not just fix disease, but to truly enhance human life?
We explore longevity, prevention, performance and what the most advanced medicine in the world is learning about how to live well for longer.
Dr Jack Kreindler qualified in medicine from University College London, spent a decade as an emergency physician and founded the Centre for Health and Human Performance in Harley Street in 2007. He is an honorary clinical research fellow at Imperial College London and a leading voice on healthy longevity and the future of medicine.
What we explore together:
•Why medicine is shifting from fixing disease to enhancing physiology
•What burning the candle at three ends is actually doing to your brain and body
•Why cadence is king and how everything in biology moves in waves
•The truth about longevity supplements, peptides and biohacking
•Why your history is still the most powerful diagnostic tool ever invented
•What it really means to enhance a human life rather than just extend it
Love, Sarah Ann 💛
My book 'Healthy Shouldn't Be This Hard': amazon.co.uk/Healthy-Shouldnt-Be-This-Hard-ebook/dp/B0G1DHNRV5
This episode is sponsored by:
NOWATCH: The compassionate health tracker Connecting body and mind with unique stress recovery insights so you can live fully today
👉 15% off with code LWBW15 at nowatch.com
PULSETTO: Vagus nerve stimulation for stress, sleep and calm
👉 Use code SARAHANN at pulsetto.sjv.io/SARAHANN
The Great British Veg Out
👉 https://sarahmacklin.substack.com/p/t…
Reset Your Health
👉 https://sarahmacklin.substack.com/s/r...
👉 Free 5-recipe PDF: sarahannmacklin.com/5_free_recipes
👉 The Compassionate Cure: sarahmacklin.substack.com
Let's be friends!
📷 Instagram: instagram.com/sarahannmacklin
📹 Subscribe: youtube.com/@livewellbewellsarah
🐦 Twitter: https://x.com/SarahAnnMacklin
📱 TikTok: tiktok.com/@livewellbewellpodcast
💌 Newsletter: sarahmacklin.substack.com
Chapters
00:00 Introduction
02:59 How Jack's view of medicine changed over 26 years
05:58 Burning the candle at three ends
09:04 Why cadence is king
12:00 A prevention first approach to health
15:07 The most powerful diagnostic tool ever invented
18:00 Advanced health testing and what it reveals
24:08 Sleep, stress and your biology
30:00 Hormones, menopause and andropause
36:00 Brain health and dementia risk
42:00 The gut microbiome
48:00 The longevity space and what the evidence shows
51:07 Peptides, supplements and biohacking
57:07 AI and the future of personalised medicine
63:02 What WellFounded Health does differently
69:08 What enhancing a human life really means
75:02 Final thoughts on living well and being well
This week I'm joined by Dr Jack Kreindler, physician, healthtech entrepreneur and founder of WellFounded Health, and someone who has spent 26 years asking one of the most important questions in medicine, what does it mean to not just fix disease, but to truly enhance human life?
We explore longevity, prevention, performance and what the most advanced medicine in the world is learning about how to live well for longer.
Dr Jack Kreindler qualified in medicine from University College London, spent a decade as an emergency physician and founded the Centre for Health and Human Performance in Harley Street in 2007. He is an honorary clinical research fellow at Imperial College London and a leading voice on healthy longevity and the future of medicine.
What we explore together:
•Why medicine is shifting from fixing disease to enhancing physiology
•What burning the candle at three ends is actually doing to your brain and body
•Why cadence is king and how everything in biology moves in waves
•The truth about longevity supplements, peptides and biohacking
•Why your history is still the most powerful diagnostic tool ever invented
•What it really means to enhance a human life rather than just extend it
Love, Sarah Ann 💛
My book 'Healthy Shouldn't Be This Hard': amazon.co.uk/Healthy-Shouldnt-Be-This-Hard-ebook/dp/B0G1DHNRV5
This episode is sponsored by:
NOWATCH: The compassionate health tracker Connecting body and mind with unique stress recovery insights so you can live fully today
👉 15% off with code LWBW15 at nowatch.com
PULSETTO: Vagus nerve stimulation for stress, sleep and calm
👉 Use code SARAHANN at pulsetto.sjv.io/SARAHANN
The Great British Veg Out
👉 https://sarahmacklin.substack.com/p/t…
Reset Your Health
👉 https://sarahmacklin.substack.com/s/r...
👉 Free 5-recipe PDF: sarahannmacklin.com/5_free_recipes
👉 The Compassionate Cure: sarahmacklin.substack.com
Let's be friends!
📷 Instagram: instagram.com/sarahannmacklin
📹 Subscribe: youtube.com/@livewellbewellsarah
🐦 Twitter: https://x.com/SarahAnnMacklin
📱 TikTok: tiktok.com/@livewellbewellpodcast
💌 Newsletter: sarahmacklin.substack.com
Chapters
00:00 Introduction
02:59 How Jack's view of medicine changed over 26 years
05:58 Burning the candle at three ends
09:04 Why cadence is king
12:00 A prevention first approach to health
15:07 The most powerful diagnostic tool ever invented
18:00 Advanced health testing and what it reveals
24:08 Sleep, stress and your biology
30:00 Hormones, menopause and andropause
36:00 Brain health and dementia risk
42:00 The gut microbiome
48:00 The longevity space and what the evidence shows
51:07 Peptides, supplements and biohacking
57:07 AI and the future of personalised medicine
63:02 What WellFounded Health does differently
69:08 What enhancing a human life really means
75:02 Final thoughts on living well and being well
