Quick Biochemistry Basics | Lock and Key model @quickbiochemistrybasics | Uploaded 4 years ago | Updated 18 hours ago
Enzymology | Lock and key model
The lock and key model is one of the earliest model proposed for the mechanism of enzyme action. It was proposed based on the fact that the enzymes are very specific for their substrates. This is just like keys are specific for their locks. According to this model, the active site of enzyme has same conformation as that of the substrate. This allows binding of the substrate in the active site of the enzyme, just like a key fits in lock. The enzyme then acts on the substrate and convert it into a product. One of The major drawback of this proposal is that it fails to explain the transition state that occurs when enzyme binds with its substrate
Enzymology | Lock and key model
The lock and key model is one of the earliest model proposed for the mechanism of enzyme action. It was proposed based on the fact that the enzymes are very specific for their substrates. This is just like keys are specific for their locks. According to this model, the active site of enzyme has same conformation as that of the substrate. This allows binding of the substrate in the active site of the enzyme, just like a key fits in lock. The enzyme then acts on the substrate and convert it into a product. One of The major drawback of this proposal is that it fails to explain the transition state that occurs when enzyme binds with its substrate
