Uploaded November 2022 | Updated September 2026, 3 weeks ago
In this video I spoke with Rich Miller, Professor of Pathology at the University of Michigan and the Director of Michigan’s Paul F. Glenn Center for Biology of Aging Research. He also contributes to the Interventions Testing Program (ITP), created in the early 2000s to study the effect of various drugs on lifespan in mice. The ITP has produced evidence for anti-aging drugs, such as rapamycin, and, in contrast, has shown a lack of effectiveness for several agents, such as metformin. We discuss the ITP findings, the biology of aging and the important questions still to address.
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Timestamps:
Intro - 00:00
Interests in aging - 01:00
Mice as a model organism - 04:00
Lessons from the ITP - 06:00
Rapamycin, mTOR & cap-independent translation - 21:00
Combining therapies - 32:30
Brain health & glucose - 35:30
Theories of aging - 44:00
DNA methylation - 49:00
Advice - 53:00
Please note that The Sheekey Science Show is distinct from Eleanor Sheekey's teaching and research roles at the University of Cambridge. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Sheekey Science Show and guests assume no liability for the application of the information discussed.
Icons in intro; "freepik.com/free-photos-vectors/background"Background vector created by freepik - freepik.com
In this video I spoke with Rich Miller, Professor of Pathology at the University of Michigan and the Director of Michigan’s Paul F. Glenn Center for Biology of Aging Research. He also contributes to the Interventions Testing Program (ITP), created in the early 2000s to study the effect of various drugs on lifespan in mice. The ITP has produced evidence for anti-aging drugs, such as rapamycin, and, in contrast, has shown a lack of effectiveness for several agents, such as metformin. We discuss the ITP findings, the biology of aging and the important questions still to address.
Find me on Twitter - twitter.com/EleanorSheekey
Support the channel
through PayPal - paypal.me/sheekeyscience?country.x=GB&locale.x=en_GB
through Patreon - patreon.com/TheSheekeyScienceShow
Timestamps:
Intro - 00:00
Interests in aging - 01:00
Mice as a model organism - 04:00
Lessons from the ITP - 06:00
Rapamycin, mTOR & cap-independent translation - 21:00
Combining therapies - 32:30
Brain health & glucose - 35:30
Theories of aging - 44:00
DNA methylation - 49:00
Advice - 53:00
Please note that The Sheekey Science Show is distinct from Eleanor Sheekey's teaching and research roles at the University of Cambridge. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Sheekey Science Show and guests assume no liability for the application of the information discussed.
Icons in intro; "freepik.com/free-photos-vectors/background"Background vector created by freepik - freepik.com
