Uploaded March 2022 | Updated September 2026, 3 weeks ago
The power of the four Yamanaka factors (OSKM) to reprogram differentiated cells into stem cells is well described. But this powerful reprogramming can cause a cell to lose its identity. A safer approach is partial reprogramming. This can be achieved if the expression of the Yamanaka factors can be controlled.
In a recent study they examine the molecular impact (gene expression, DNA methylation and metabolites) of a single OSKM expression event.
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TIMESTAMPS:
Intro - 00:00
Rejuvenation recap - 00:45
Single OSKM changes - 02:15
References:
Multi-omic rejuvenation of naturally aged tissues by a single cycle of transient reprogramming - doi.org/10.1111/acel.13578
Abad, M., Mosteiro, L., Pantoja, C. et al. Reprogramming in vivo produces teratomas and iPS cells with totipotency features. Nature 502, 340–345 (2013). doi.org/10.1038/nature12586
Please note that The Sheekey Science Show is distinct from Eleanor Sheekey's teaching and research roles at the University of Cambridge. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Sheekey Science Show and guests assume no liability for the application of the information discussed.
Icons in intro; "freepik.com/free-photos-vectors/background"Background vector created by freepik - freepik.com
The power of the four Yamanaka factors (OSKM) to reprogram differentiated cells into stem cells is well described. But this powerful reprogramming can cause a cell to lose its identity. A safer approach is partial reprogramming. This can be achieved if the expression of the Yamanaka factors can be controlled.
In a recent study they examine the molecular impact (gene expression, DNA methylation and metabolites) of a single OSKM expression event.
Find me on Twitter - twitter.com/EleanorSheekey
Support the channel
through PayPal - paypal.me/sheekeyscience?country.x=GB&locale.x=en_GB
through Patreon - patreon.com/TheSheekeyScienceShow
TIMESTAMPS:
Intro - 00:00
Rejuvenation recap - 00:45
Single OSKM changes - 02:15
References:
Multi-omic rejuvenation of naturally aged tissues by a single cycle of transient reprogramming - doi.org/10.1111/acel.13578
Abad, M., Mosteiro, L., Pantoja, C. et al. Reprogramming in vivo produces teratomas and iPS cells with totipotency features. Nature 502, 340–345 (2013). doi.org/10.1038/nature12586
Please note that The Sheekey Science Show is distinct from Eleanor Sheekey's teaching and research roles at the University of Cambridge. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Sheekey Science Show and guests assume no liability for the application of the information discussed.
Icons in intro; "freepik.com/free-photos-vectors/background"Background vector created by freepik - freepik.com
