Interstate 22: Tupelo, MS to Birmingham, AL | Real Roads, Real Drives [Repost/Revisited] @realroadsmedia
Interstate 22: Tupelo, MS to Birmingham, AL | Real Roads, Real Drives [Repost/Revisited]  @realroadsmedia
Uploaded August 2025 | Updated September 2026, 2 weeks ago
🚙 Drive America’s Highways for 128 miles east along Interstate 22 from Tupelo, Mississippi, to Birmingham, Alabama. 🛣️

The drive begins in Tupelo as Interstate 22 merges from the Natchez Trace Parkway interchange. Almost immediately, the route crosses U.S. Highway 45 at a full cloverleaf, providing connections north toward Corinth and south toward Columbus. Leaving Tupelo behind, I-22 travels eastward across the rolling hills of northeastern Mississippi, serving the towns of Fulton and Tremont before reaching the Alabama state line. This section highlights the relatively new construction of I-22, a modern corridor built to provide a high-speed link between Memphis and Birmingham along the historic U.S. 78 alignment.

Crossing into Alabama, the highway takes on a more southeasterly direction just before Hamilton, offering access to U.S. Highway 278 and Alabama Highway 13. From here, the route threads through the Appalachian foothills, passing wooded ridges and valleys on the approach to Jasper, one of the larger communities along the corridor. South of Jasper, I-22 shifts more directly toward Birmingham, skirting Cordova before intersecting U.S. Highway 78 near Graysville. The final leg carries traffic past several local interchanges before reaching its eastern terminus at Interstate 65 north of downtown Birmingham. The video concludes at this major interchange, where I-22 officially ends and traffic can continue south toward the heart of Birmingham or north toward Cullman and Huntsville.
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Interstate 22: Tupelo, MS to Birmingham, AL | Real Roads, Real Drives [Repost/Revisited]

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