Uploaded January 2026 | Updated September 2026, 2 weeks ago
Dr. Michael Levin is the Vannevar Bush Distinguished Professor of Biology at Tufts University and director of the Allen Discovery Center. He is primarily interested in how intelligence self-organizes in a diverse range of natural, engineered, and hybrid embodiments. Applied to the collective intelligence of cell groups undergoing morphogenesis, these ideas have allowed the Levin Lab to develop new applications in birth defects, organ regeneration, and cancer suppression.
This episode is brought to you by:
ShipStation shipping software: ShipStation.com/Tim
AG1 all-in-one nutritional supplement: DrinkAG1.com/Tim
Our Place’s Titanium Always Pan® Pro using nonstick technology that’s coating-free and made without PFAS, otherwise known as “forever chemicals”: FromOurPlace.com/Tim
[00:00] Preview.
[00:42] The Body Electric: A Vancouver bookstore discovery that launched a career.
[01:44] Bioelectricity 101: Your brain uses it to think; your body used it before you had a brain.
[03:29] The lesson learned by scrambled tadpole faces that rearrange themselves.
[06:21] Software vs. hardware: The genome is your factory settings, not your destiny.
[09:14] Two-headed flatworms: Rewriting biological memory without touching DNA.
[11:19] Seeing memories: Voltage-sensitive dyes reveal the body’s hidden blueprints.
[15:17] Three killer apps for humans: Birth defects, regeneration, and cancer.
[19:39] Cancer as identity crisis: Cells forgetting they’re part of a team.
[20:54] The boredom theory of aging: Goal-seeking systems with nothing left to do.
[25:41] Planaria’s immortality hack: Rip yourself in half every two weeks.
[27:04] Manhattan Project for aging: Crack cellular cognition, everything else falls into place.
[29:30] Giving cells new goals: Convince a gut to become an eye.
[33:32] Must mammalian mortality be mandatory?
[36:24] Cross-pollination: Why biologists would benefit from programming courses.
[42:19] Does acupuncture actually do anything?
[46:09] Placebo as feature, not bug: Words and drugs share the same mechanism.
[50:24] The frame problem: Why robots explode and rats intuit what matters.
[55:04] Binary thinking is a trap: “Is it intelligent?” is the wrong question.
[01:03:23] Minimal brain, normal IQ: Clinical cases that break neuroscience.
[01:04:24] Super panpsychism: Your liver might have opinions.
[01:09:36] The Platonic space: Bodies as thin clients for patterns from elsewhere.
[01:11:19] Keep asking “why” and you end up in the math department.
[01:19:06] Polycomputing: Sorting algorithms secretly doing side quests.
[01:24:38] Power scaling for the future and avoiding red herrings for understanding machine minds.
[01:30:28] Sci-fi recommendations.
[01:33:38] Cliff Tabin’s toast and Dan Dennett’s steel manning.
[01:37:32] Parting thoughts.
Tim Ferriss is one of Fast Company’s “Most Innovative Business People” and an early-stage tech investor/advisor in Uber, Facebook, Twitter, Shopify, Duolingo, Alibaba, and 50+ other companies. He is also the author of five #1 New York Times and Wall Street Journal bestsellers: The 4-Hour Workweek, The 4-Hour Body, The 4-Hour Chef, Tools of Titans and Tribe of Mentors. The Observer and other media have named him “the Oprah of audio” due to the influence of his podcast, The Tim Ferriss Show, which has exceeded one billion downloads and been selected for “Best of Apple Podcasts” three years running.
Sign up for "5-Bullet Friday" (Tim's free weekly email newsletter): https://go.tim.blog/5-bullet-friday-yt/
Follow the Tim Ferriss Podcast: https://tim.blog/podcast/
Visit the Tim Ferriss Blog: https://tim.blog/
Follow Tim Ferriss on Twitter: twitter.com/tferriss
Follow Tim Ferriss on Instagram: instagram.com/timferriss
Like Tim Ferriss on Facebook: facebook.com/TimFerriss
Dr. Michael Levin is the Vannevar Bush Distinguished Professor of Biology at Tufts University and director of the Allen Discovery Center. He is primarily interested in how intelligence self-organizes in a diverse range of natural, engineered, and hybrid embodiments. Applied to the collective intelligence of cell groups undergoing morphogenesis, these ideas have allowed the Levin Lab to develop new applications in birth defects, organ regeneration, and cancer suppression.
This episode is brought to you by:
ShipStation shipping software: ShipStation.com/Tim
AG1 all-in-one nutritional supplement: DrinkAG1.com/Tim
Our Place’s Titanium Always Pan® Pro using nonstick technology that’s coating-free and made without PFAS, otherwise known as “forever chemicals”: FromOurPlace.com/Tim
[00:00] Preview.
[00:42] The Body Electric: A Vancouver bookstore discovery that launched a career.
[01:44] Bioelectricity 101: Your brain uses it to think; your body used it before you had a brain.
[03:29] The lesson learned by scrambled tadpole faces that rearrange themselves.
[06:21] Software vs. hardware: The genome is your factory settings, not your destiny.
[09:14] Two-headed flatworms: Rewriting biological memory without touching DNA.
[11:19] Seeing memories: Voltage-sensitive dyes reveal the body’s hidden blueprints.
[15:17] Three killer apps for humans: Birth defects, regeneration, and cancer.
[19:39] Cancer as identity crisis: Cells forgetting they’re part of a team.
[20:54] The boredom theory of aging: Goal-seeking systems with nothing left to do.
[25:41] Planaria’s immortality hack: Rip yourself in half every two weeks.
[27:04] Manhattan Project for aging: Crack cellular cognition, everything else falls into place.
[29:30] Giving cells new goals: Convince a gut to become an eye.
[33:32] Must mammalian mortality be mandatory?
[36:24] Cross-pollination: Why biologists would benefit from programming courses.
[42:19] Does acupuncture actually do anything?
[46:09] Placebo as feature, not bug: Words and drugs share the same mechanism.
[50:24] The frame problem: Why robots explode and rats intuit what matters.
[55:04] Binary thinking is a trap: “Is it intelligent?” is the wrong question.
[01:03:23] Minimal brain, normal IQ: Clinical cases that break neuroscience.
[01:04:24] Super panpsychism: Your liver might have opinions.
[01:09:36] The Platonic space: Bodies as thin clients for patterns from elsewhere.
[01:11:19] Keep asking “why” and you end up in the math department.
[01:19:06] Polycomputing: Sorting algorithms secretly doing side quests.
[01:24:38] Power scaling for the future and avoiding red herrings for understanding machine minds.
[01:30:28] Sci-fi recommendations.
[01:33:38] Cliff Tabin’s toast and Dan Dennett’s steel manning.
[01:37:32] Parting thoughts.
Tim Ferriss is one of Fast Company’s “Most Innovative Business People” and an early-stage tech investor/advisor in Uber, Facebook, Twitter, Shopify, Duolingo, Alibaba, and 50+ other companies. He is also the author of five #1 New York Times and Wall Street Journal bestsellers: The 4-Hour Workweek, The 4-Hour Body, The 4-Hour Chef, Tools of Titans and Tribe of Mentors. The Observer and other media have named him “the Oprah of audio” due to the influence of his podcast, The Tim Ferriss Show, which has exceeded one billion downloads and been selected for “Best of Apple Podcasts” three years running.
Sign up for "5-Bullet Friday" (Tim's free weekly email newsletter): https://go.tim.blog/5-bullet-friday-yt/
Follow the Tim Ferriss Podcast: https://tim.blog/podcast/
Visit the Tim Ferriss Blog: https://tim.blog/
Follow Tim Ferriss on Twitter: twitter.com/tferriss
Follow Tim Ferriss on Instagram: instagram.com/timferriss
Like Tim Ferriss on Facebook: facebook.com/TimFerriss



![Movement Coach Nsima Inyang — True Athleticism at Any Age
Nsima Inyang is a strength athlete, movement coach, and co-host of Mark Bell’s Power Project, one of the top fitness podcasts in the world. He is also one of the most freakishly athletic humans I’ve ever met. He’s a black belt in Brazilian jiu-jitsu, a professional natural bodybuilder (placed top five in the world), and an elite-level powerlifter (750-plus-pound deadlift, etc.)—but what sets him apart is how he blends all those worlds with unconventional training tools like kettlebells, maces, sandbags, and rope flow. Nsima is also the founder of The Stronger Human, a growing online community focused on strength, movement, and resilience.
This episode is brought to you by:
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*
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The Stronger Human Store: https://thestrongerhuman.store/
For show notes and past guests on The Tim Ferriss Show, please visit https://tim.blog/podcast.
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Sign up for Tim’s email newsletter (5-Bullet Friday) at https://tim.blog/friday.
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LinkedIn: https://linkedin.com/in/timferriss
[00:00] Start/preview
[00:40] Defining powerlifting and Nsimas elite totals.
[03:22] Nsimas first video that grabbed my attention.
[04:19] Serge Gracovetsky and The Spinal Engine.
[05:12] How Nsima avoids the distinctive plane-bound movement of many bodybuilders.
[09:59] My tango struggles and coping with the waist of a chicken.
[11:30] Intro to rope flow and David Weck.
[13:40] Rope flow benefits, mechanics, and efficacy as an internal martial art.
[28:02] Minimum effective dose rope flow.
[30:22] Rope flow equipment and costs.
[32:20] Bill Maeda and movement as daily practice.
[35:37] How my three years of chronic pain and movement limitations might have been solved by breathing properly.
[42:10] Lower body training: unilateral before bilateral, sandbags vs. barbells.
[46:02] Box squats and safety: managing compression sensitivity and range of motion.
[52:42] Set rep programming for non-elite powerlifters.
[59:43] Eschew the monotonous. Embrace the exercise that inspires you.
[01:04:16] Caution: dont train your way into adopting a sub-optimal gait.
[01:06:46] Sumo deadlifting technique, Colton Engelbrecht, and Nsimas meaty hands.
[01:15:41] Ed Coan: the greatest powerlifter and his anatomical advantages.
[01:19:30] Staggered stance deadlifts
[01:21:11] Bang-for-buck exercises: kettlebell swings and sandbag training benefits.
[01:24:58] Cossack squats and adductor training: addressing weak links in movement.
[01:28:35] Ankle mobility, Ben Patrick, and ATG methods.
[01:33:08] How regression solved Nsimas chronic knee injury pain.
[01:35:19] Scale it down philosophy: the importance of ego-free progression.
[01:42:57] Microdosing movement: small daily doses vs. intensive sessions.
[01:47:32] Placing equipment strategically for daily use.
[01:54:12] Calisthenics and body weight strength: why barbells dont equal body control.
[02:01:07] Rock climbing inspiration: 70-year-olds outperforming younger athletes.
[02:04:10] Non-negotiable lifts: sled work as the foundation movement.
[02:17:51] Kelly Starrett and soft tissue work fundamentals.
[02:22:35] Self-massage tools and techniques: from Gua Sha to Body Lever to tennis balls.
[02:29:30] Evidence-based fitness limitations: not waiting for papers to validate effective practices.
[02:34:27] Nightly protocols, acupressure, and Andrii Bondarenko.
[02:41:31] Learning to heal yourself: developing internal reference points for soft tissue work.
[02:42:35] Back buddies and medicine balls.
[02:45:34] Nordic curls challenge: beating Tyreek Hills record through systematic progression.
[02:51:39] Bone density fundamentals: compression, tension, impact, and rotation stressors.
[02:54:21] Jumping and rebounding: why we stop jumping and how to regress back to it.
[03:02:26] What Nsima hopes to convey to his audience online and where he can be found.
[03:04:19] Gratitude: how this podcast influenced Nsimas learning journey from age 20.
[03:05:27] Micro-progressions, sustainable movement practice, and parting thoughts. Movement Coach Nsima Inyang — True Athleticism at Any Age](https://i.ytimg.com/vi/mLGqrlxofXA/mqdefault.jpg)


![Reimagining Biotech with Jake Becraft of Strand Therapeutics — Tim’s Founder Kitchen
Jake Becraft is the CEO and co-founder of Strand Therapeutics, a company building one of the most advanced programmable genetic medicine platforms in biotechnology. Under his leadership, Strand is redefining what RNA medicines can do by enabling cell-selective targeting and therapeutic payload delivery inside the body, unlocking a new class of precision genetic therapies.
This episode is brought to you by:
Helix Sleep premium mattresses: https://HelixSleep.com/Tim (20% off any purchase)
Incogni, which automatically removes your personal data from the web, helping shield you from fraud, scams, and identity theft: https://Incogni.com/Tim (use code TIM at checkout and get 60% off an annual plan)
This episode is an experiment. Im trying out a new format — half interview, half live jam session. Ive started a new series, working title Tims Founder Kitchen, built around actual brainstorming sessions with founders willing to share the audio. This first installment is with Jake Becraft of Strand Therapeutics—one of the companies Im most excited about—and its a two-part conversation that lets you track a positioning and comms discussion from a raw early-stage session all the way through to the real-world results it produced a couple months later. Its a rare before-and-after, and I genuinely want your feedback: let me know on X @tferriss what you think and how I can make it better.
[00:00] Preview.
[00:48] What Strand does.
[02:58] The Boston dinner.
[05:56] The image of a body riddled with cancer.
[09:58] What stuck for the muggles in the pitch deck.
[12:03] A good drug vs. a good product.
[14:38] Tricking cancer into snitching on itself.
[20:10] The abscopal effect.
[26:57] Potency, specificity, and delivery.
[28:40] First principles thinking.
[29:32] The precipice of a revolution.
[34:10] The thousand people in the room.
[41:55] Psychedelic medicine as a cautionary tale.
[44:39] What actually catches a policymakers attention.
[47:08] Breakthrough vs. incremental.
[48:24] Whats in it for the policymakers?
[51:40] The 80/20 wish list.
[55:04] Australias CTN system.
[57:22] Sheep, psychedelics, and red-tape arbitrage.
[58:54] Chinas clinical-trial flywheel vs. slow-motion American loss.
[1:00:28] The bicoastal biotech ethos.
[1:01:41] Can the FDA actually pull this off?
[1:05:46] The Sophies Choice of pharma development.
[1:07:48] Lost arts of founder mode.
[1:09:03] Rockets for tumors, T-cells, and beyond.
[1:12:45] Viral in policy circles.
[1:16:55] The Washington Post headline and the PickFu split test.
[1:21:53] Solution-first storytelling.
[1:28:01] RNA Medicine and Platform Therapeutics.
[1:33:41] Modernas 62 days.
[1:35:08] Uber Eats and the de-risked launch.
[1:38:39] CEO blockers.
[1:40:14] Wheres biotechs SpaceX moment?
[1:41:14] Elon Musk betting black on the wheel.
[1:46:21] AWS and the post-conviction/pre-consensus window.
[1:53:20] COVID politicization.
[1:54:20] Insulin, growth hormone, and the original platform story.
[1:56:10] Biotech as pharmas little brother.
[1:58:04] More recent role models, Apple edition.
[1:59:22] Art Levinson, Steve Jobs, and the biotech-tech crossover.
[2:00:58] The iPhone as a delivery platform.
[2:03:00] Spotifys problem and the future of bespoke medicine.
[2:04:41] Baby KJ and the limits of liver-only solutions.
[2:05:56] Parting thoughts.
https://x.com/tferriss
Tim Ferriss is one of Fast Company’s “Most Innovative Business People” and an early-stage tech investor/advisor in Uber, Facebook, Twitter, Shopify, Duolingo, Alibaba, and 50+ other companies. He is also the author of five #1 New York Times and Wall Street Journal bestsellers: The 4-Hour Workweek, The 4-Hour Body, The 4-Hour Chef, Tools of Titans and Tribe of Mentors. The Observer and other media have named him “the Oprah of audio” due to the influence of his podcast, The Tim Ferriss Show, which has exceeded one billion downloads and been selected for “Best of Apple Podcasts” three years running.
Sign up for 5-Bullet Friday (Tims free weekly email newsletter): https://go.tim.blog/5-bullet-friday-yt/
Follow the Tim Ferriss Podcast: https://tim.blog/podcast/
Visit the Tim Ferriss Blog: https://tim.blog/
Follow Tim Ferriss on Twitter: https://twitter.com/tferriss/
Follow Tim Ferriss on Instagram: https://www.instagram.com/timferriss/
Like Tim Ferriss on Facebook: https://www.facebook.com/TimFerriss/ Reimagining Biotech with Jake Becraft of Strand Therapeutics — Tim’s Founder Kitchen](https://i.ytimg.com/vi/mZ-vJ6kDRD0/mqdefault.jpg)
![David Senra — How Extreme Winners Think and Win: Lessons from 400+ of History’s Greatest Founders
David Senra is the host of the Founders podcast. For the past nine years, David has intensely studied the life and work of hundreds of history’s greatest entrepreneurs. His new podcast, David Senra, showcases conversations with the best-of-the-best living founders and extreme winners.
This episode is brought to you by:
Cresset family office services for CEOs, founders, and entrepreneurs: https://cressetcapital.com/tim
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AG1 all-in-one nutritional supplement: https://drinkag1.com/tim
***
David Senra: https://davidsenra.com/
[00:00:00] Coming up
[00:32] Brad Jacobs
[01:52] Rare positive archetypes
[05:26] Michael Dell
[06:11] Negative self-talk, excellence, and its ripple effects.
[07:54] Jensen Huang
[08:24] Dan Carlin’s Hardcore History.
[09:28] Derek Sivers
[10:34] Learning equals behavior change, not memorization.
[11:20] Jeremy Giffon insight: biographies as substitute mentors.
[13:45] Podcasting as “relationships at scale.”
[14:04] Coping with trauma and breaking cycles.
[15:33] Note-taking process
[24:44] OCD tendencies and love of doing things the hard way.
[30:24] A family falling out and the randomness of student housing.
[34:38] David’s introduction to my work during his MySpace-era college years.
[35:42] Podcasting influences: Jocko Willink, Kevin Rose’s Elon Musk interview.
[38:34] 5+ years of obscurity before breakthrough.
[43:41] Patrick O’Shaughnessy’s endorsement sparks growth.
[49:34] Edwin Land
[51:23] Lessons from Sam Zell, Jay Pritzker, and William Zeckendorf.
[57:29] Edwin Land’s philosophies: Differentiation and doing to excess.
[58:52] Entrepreneurial archetypes and conflicting advice.
[01:00:25] Daniel Ek
[01:05:21] Further founder archetypes
[01:08:12] Anti-business billionaire?
[01:14:35] Advice from “shark” Michael Ovitz
[01:17:13] The hands-on approach of practical founders
[01:18:14] Doing one thing relentlessly.
[01:18:36] “This can’t be my life” as a powerful motivator.
[01:21:40] Low introspection as a common trait among founders
[01:24:33] Robert Caro.
[01:27:15] James Dyson’s persistence vs. the risk of blind stubbornness.
[01:28:56] Todd Graves (Raising Cane’s) as an example of relentless focus on one idea.
[01:36:10] Considering trainable vs. non-trainable attributes
[01:40:19] Charlie Munger’s library.
[01:43:32] Dealmaking lessons on Eddie Lampert’s superyacht.
[01:50:30] David’s obsessive craftsman approach to podcast creation.
[01:52:20] Why David decided to begin a second podcast.
[01:57:00] The benefits of cultivating a purposeful aloofness about current events.
[02:02:54] New show frequency/dynamic and how David plans to balance the burden of running two shows.
[02:08:30] Rockefellers “secret allies” strategy
[02:10:28] Chris Hutchins: The mad scientist of podcasting?
[02:10:58] Working with Rob Mohr and Andrew Huberman.
[02:17:18] Does David worry that the extra workload will disrupt his lifestyle?
[02:26:13] Impact vs. happiness.
[02:28:27] Playing the status game when your heart’s not in it is for suckers.
[02:26:05] Travel observations and the rarity of truly unique experiences.
[02:38:10] Books as philosophical operating systems.
Sign up for 5-Bullet Friday (Tims free weekly email newsletter): https://go.tim.blog/5-bullet-friday-yt/
Follow the Tim Ferriss Podcast: https://tim.blog/podcast/
Visit the Tim Ferriss Blog: https://tim.blog/
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Follow Tim Ferriss on Instagram: https://www.instagram.com/timferriss/
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![How to Use Ketosis for Enhanced Mood, Cognition, and Long-Term Brain Protection — Dr. Dom DAgostino
Dr. Dominic D’Agostino is a tenured associate professor in the Department of Molecular Pharmacology and Physiology at the University of South Florida Morsani College of Medicine and a Visiting Senior Research Scientist at the Institute for Human and Machine Cognition.
This episode is brought to you by:
Gusto simple and easy payroll, HR, and benefits platform used by 400,000+ businesses: https://gusto.com/tim
Seeds DS-01® Daily Synbiotic broad spectrum 24-strain probiotic + prebiotic: https://Seed.com/Tim
David Protein Bars 28g of protein, 150 calories, and 0g of sugar: https://davidprotein.com/tim
Coyote the card game, which I co-created with Exploding Kittens: https://coyotegame.com
[00:00] Preview.
[00:49] Ketosis benefits: Quieting the mind, GABA elevation, metabolic psychiatry.
[05:50] My Lyme disease story: Pseudo-dementia reversed in 3-4 days of ketosis.
[09:53] Spirochetes are glycolytic: Starve the bug, boost the immune response.
[13:33] Ketosis and cancer: Slowing glycolytic tumors, enhancing standard care.
[15:07] My 18-day keto experiment: Mood stabilization, Alzheimer’s prevention hopes.
[17:40] Metabolic memory: Carryover effects and Valter Longo’s fasting mimicking research.
[21:39] Intermittent fasting as keto on-ramp: My 2-8 p.m. eating window.
[23:49] Dom’s budget keto meal: Canned mackerel, MCT oil, apple cider vinegar.
[28:12] My ketone measurement paradox: Feeling sharp at 0.2 mM readings.
[31:42] The carburetor analogy: Ketone production vs. utilization explained.
[33:34] Breath ketones vs. blood ketones: Better indicator in caloric deficit.
[34:40] Gluconeogenesis fears: Fat, fiber, and salt to slow protein absorption.
[37:52] The bunless double cheeseburger question: 80 grams of protein in one sitting.
[41:38] Post-meal walking and GLUT4 activation: Timing your glucose disposal.
[43:35] CGM and ketone monitor limitations: When your devices gaslight you.
[50:41] Rabbit starvation and protein-veggie days: Why your body won’t bankroll its own ketosis.
[58:16] Alzheimer’s prevention: Biomarkers, B12, hsCRP, and metabolic health.
[01:02:15] My family history: Letrozole, metabolic dysfunction, and rapid cognitive decline.
[01:05:55] Minimum effective dose: 80% of benefits from low-carb Mediterranean.
[01:11:41] One week per month protocol: Aggressive calorie cut to ramp ketones.
[01:16:07] GKI sweet spot: Target 1-4, aim for 1-2 during intensive weeks.
[01:28:57] Exogenous ketones 101: Palatability, tolerability, pharmacokinetics, toxicity.
[01:31:58] 1,3-Butanediol warnings: Liver toxicity, NAD depletion, dependency risk.
[01:47:13] Intermittent fasting vs. ketogenic breakfast.
[01:52:04] My accidental intoxication story.
[01:56:14] Dr. Veech tribute: Student of Hans Krebs, ketone ester pioneer.
[01:57:58] Fiber on keto: Wild blueberries, broccoli, apples, walnuts.
[02:02:37] The tainted gummies incident: Dom’s forensic investigation underway.
[02:05:46] Thanks to Dr. Boz and Medifoodz.
[02:08:56] Parting thoughts.
Tim Ferriss is one of Fast Company’s “Most Innovative Business People” and an early-stage tech investor/advisor in Uber, Facebook, Twitter, Shopify, Duolingo, Alibaba, and 50+ other companies. He is also the author of five #1 New York Times and Wall Street Journal bestsellers: The 4-Hour Workweek, The 4-Hour Body, The 4-Hour Chef, Tools of Titans and Tribe of Mentors. The Observer and other media have named him “the Oprah of audio” due to the influence of his podcast, The Tim Ferriss Show, which has exceeded one billion downloads and been selected for “Best of Apple Podcasts” three years running.
Sign up for 5-Bullet Friday (Tims free weekly email newsletter): https://go.tim.blog/5-bullet-friday-yt/
Follow the Tim Ferriss Podcast: https://tim.blog/podcast/
Visit the Tim Ferriss Blog: https://tim.blog/
Follow Tim Ferriss on Twitter: https://twitter.com/tferriss/
Follow Tim Ferriss on Instagram: https://www.instagram.com/timferriss/
Like Tim Ferriss on Facebook: https://www.facebook.com/TimFerriss/ How to Use Ketosis for Enhanced Mood, Cognition, and Long-Term Brain Protection — Dr. Dom DAgostino](https://i.ytimg.com/vi/ncnFrh2rdpY/mqdefault.jpg)
