Uploaded November 2021 | Updated September 2026, 2 weeks ago

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The mechanism for a Doebner reaction which is a three component coupling of an aniline, pyruvic acid, and an aldehyde to yield a 4-carboxyl quinoline. That product can be decarboxylated to furnish a quinoline. The mechanism begins with a condensation with the formed intermediate being attacked by the enol. This is followed by intramolecular condensation and oxidation to yield the final product.

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