Uploaded April 2022 | Updated September 2026, 1 week ago

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In this episode, I go through the reduction of carbonyls to CH2s using the Mozingo, Wolff-Kishner & Clemmensen reduction. I also go through the Corey-Seebach reaction.

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Links to articles discussed in this episode:
first Mozingo reduction - doi.org/10.1021/ja9743194
second Mozingo reduction - doi.org/10.1016/S0223-5234(99)80078-6
first Wolff-Kischner reduction - doi.org/10.1016/j.tetlet.2013.11.080
second Wolff-Kischner reduction - doi.org/10.1016/j.polymer.2013.06.018
first Clemmensen reduction - doi.org/10.1021/jo00298a029
second Clemmensen reduction - doi.org/10.1021/acs.orglett.9b02511
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I hope you enjoyed the video! I'm planning on making a full series of videos if these videos are helpful for people!

Recommended Texts:
J. Clayden, N. Greeves, S. Warren, Organic Chemistry Second Edition, Oxford University Press, 2012. (especially good for mechanism and physical chemistry explanations)
T. W. G. Solomons, C. B. Fryle, S. A. Snyder, Organic Chemistry Twelfth Edition, Wiley-VCH Verlag GmbH & Co. KGaA, 2016.
LibreTexts:
chem.libretexts.org/Bookshelves/Organic_Chemistry