RCSBProteinDataBank | Build a Paper Model of a G Protein-Coupled Receptor (GPCR) @RCSBProteinDataBank | Uploaded November 2019 | Updated October 2024, 4 days ago.
This paper model represents the shared structural features of all G Protein-Coupled Receptors (GPCRs). GPCRs are a large family of membrane-embedded receptors, with structural features that have been preserved through the course of evolution. With the extracellular N-terminus, the protein chain folds to form a bundle of seven transmembrane alpha helices connected by 3 intracellular and 3 extracellular loops with the C-terminus reaching inside the cell. On the extracellular side, the helices form a cavity where ligands (e.g. endorphins, morphine, serotonin) bind. On the intracellular side, the receptor is coupled to G protein. When the receptor is activated by a ligand, the G protein splits in two parts which then activate other proteins in the internal signal transduction pathways.
Download this paper model template from PDB-101: pdb101.rcsb.org/learn/paper-models/g-protein-coupled-receptor-gpcr
This paper model represents the shared structural features of all G Protein-Coupled Receptors (GPCRs). GPCRs are a large family of membrane-embedded receptors, with structural features that have been preserved through the course of evolution. With the extracellular N-terminus, the protein chain folds to form a bundle of seven transmembrane alpha helices connected by 3 intracellular and 3 extracellular loops with the C-terminus reaching inside the cell. On the extracellular side, the helices form a cavity where ligands (e.g. endorphins, morphine, serotonin) bind. On the intracellular side, the receptor is coupled to G protein. When the receptor is activated by a ligand, the G protein splits in two parts which then activate other proteins in the internal signal transduction pathways.
Download this paper model template from PDB-101: pdb101.rcsb.org/learn/paper-models/g-protein-coupled-receptor-gpcr
