Uploaded December 2025 | Updated September 2026, 1 week ago
The discovery of a cure for hepatitis C transformed medicine and paved the way for new scientific and clinical questions. This year's Rudi Schmid Lecturer is 2020 Nobel Prize winner Charles M. Rice, PhD, whose work has been central to defining the biology of hepatitis C and informing the treatment strategies that have changed the lives of millions. He will review pivotal advances that shaped our understanding of hepatitis C; the development of increasingly effective treatments; and the challenges that remain—including the persistent risk of liver cancer in patients with hepatitis C infection, even after viral cure.
Speaker:
Charles M. Rice, PhD, is the Maurice R. and Corinne P. Greenberg Professor and Head of the Laboratory of Virology and Infectious Disease at The Rockefeller University. A leading expert on Flaviviridae viruses, including hepatitis C, he has authored more than 500 publications. He is a past president of the American Society for Virology, a fellow of the American Association for the Advancement of Science, and a member of the National Academy of Sciences and the National Academy of Medicine. His pioneering contributions to hepatitis C research earned him a share of the 2016 Lasker-DeBakey Clinical Medical Research Award and the 2020 Nobel Prize in Physiology or Medicine.
About:
The Rudi Schmid Lecture is held in honor of Rudi Schmid, MD, PhD. Born in Switzerland, Schmid received his MD degree from the University of Zurich in 1947. After an internship at UCSF and residency at the University of Minnesota, he became a faculty member at the NIH, Harvard, and the University of Chicago before joining the UCSF faculty in 1966 as professor and chief of gastroenterology. Under his leadership, our GI division became one of the country's leading research, educational, and clinical gastroenterology and hepatology units. As dean of the UCSF School of Medicine from 1983-1989, Schmid fostered the continued growth of both basic and clinical sciences. He served as president of several professional organizations, including the American Association for the Study of Liver Diseases, and received many national and international awards in recognition of outstanding achievements throughout his career.
Program:
Bob Wachter: Introduction
2:53-59:49 — Charles Rice
59:50-1:04:55 — Q&A
See previous Medical Grand Rounds:
November 18: Hollander Rounds: A Clinical Problem-Solving Case
• youtu.be/E6zuN1Tm0DQ
October 28: Ethical Cases and Conundrums in Medicine
• youtu.be/QxfKjANDQbw
October 21: ARDS: New Global Definition, Current Therapies, and Implementing Precision Critical Care
• youtu.be/FYDCUthuKkA
October 14: Advances in Care for Hospitalized Patients with Inflammatory Bowel Disease
• youtu.be/uJfzOCPNjfc
The discovery of a cure for hepatitis C transformed medicine and paved the way for new scientific and clinical questions. This year's Rudi Schmid Lecturer is 2020 Nobel Prize winner Charles M. Rice, PhD, whose work has been central to defining the biology of hepatitis C and informing the treatment strategies that have changed the lives of millions. He will review pivotal advances that shaped our understanding of hepatitis C; the development of increasingly effective treatments; and the challenges that remain—including the persistent risk of liver cancer in patients with hepatitis C infection, even after viral cure.
Speaker:
Charles M. Rice, PhD, is the Maurice R. and Corinne P. Greenberg Professor and Head of the Laboratory of Virology and Infectious Disease at The Rockefeller University. A leading expert on Flaviviridae viruses, including hepatitis C, he has authored more than 500 publications. He is a past president of the American Society for Virology, a fellow of the American Association for the Advancement of Science, and a member of the National Academy of Sciences and the National Academy of Medicine. His pioneering contributions to hepatitis C research earned him a share of the 2016 Lasker-DeBakey Clinical Medical Research Award and the 2020 Nobel Prize in Physiology or Medicine.
About:
The Rudi Schmid Lecture is held in honor of Rudi Schmid, MD, PhD. Born in Switzerland, Schmid received his MD degree from the University of Zurich in 1947. After an internship at UCSF and residency at the University of Minnesota, he became a faculty member at the NIH, Harvard, and the University of Chicago before joining the UCSF faculty in 1966 as professor and chief of gastroenterology. Under his leadership, our GI division became one of the country's leading research, educational, and clinical gastroenterology and hepatology units. As dean of the UCSF School of Medicine from 1983-1989, Schmid fostered the continued growth of both basic and clinical sciences. He served as president of several professional organizations, including the American Association for the Study of Liver Diseases, and received many national and international awards in recognition of outstanding achievements throughout his career.
Program:
Bob Wachter: Introduction
2:53-59:49 — Charles Rice
59:50-1:04:55 — Q&A
See previous Medical Grand Rounds:
November 18: Hollander Rounds: A Clinical Problem-Solving Case
• youtu.be/E6zuN1Tm0DQ
October 28: Ethical Cases and Conundrums in Medicine
• youtu.be/QxfKjANDQbw
October 21: ARDS: New Global Definition, Current Therapies, and Implementing Precision Critical Care
• youtu.be/FYDCUthuKkA
October 14: Advances in Care for Hospitalized Patients with Inflammatory Bowel Disease
• youtu.be/uJfzOCPNjfc
