The Sheekey Science Show | The future method to rejuvenate fertility? @TheSheekeyScienceShow | Uploaded February 2022 | Updated October 2024, 4 days ago.
Fertility declines with age and is impacted by genetics and other lifestyle factors. Understanding early development and gametogenesis (egg and sperm development) could lead to better treatment methods.
In this video we take a look at in vitro gametogenesis - making egg and sperm cells in a dish - using a combination of cellular reprogramming and techniques to turn human induced pluripotent stem cells into precursory egg and sperm. We also take a look at the challenges (epigenetic changes) and how the process has generated fertile offspring in mice.
Find me on Twitter - twitter.com/EleanorSheekey
Support the channel
through PayPal - paypal.me/sheekeyscience?country.x=GB&locale.x=en_GB
through Patreon - patreon.com/TheSheekeyScienceShow
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TIMESTAMPS:
Intro - 00:00
Gametogenesis - 00:25
Fertility - 01:42
In vitro gametogenesis - 03:35
Thoughts - 07:25
References:
MAMMALIAN IN VITRO GAMETOGENESIS - doi.org/10.1126/science.aaz6830
Yamashiro, C., Sasaki, K., Yokobayashi, S. et al. Generation of human oogonia from induced pluripotent stem cells in culture. Nat Protoc 15, 1560–1583 (2020). doi.org/10.1038/s41596-020-0297-5
Hwang, Y.S., Suzuki, S., Seita, Y. et al. Reconstitution of prospermatogonial specification in vitro from human induced pluripotent stem cells. Nat Commun 11, 5656 (2020). doi.org/10.1038/s41467-020-19350-3
Hikabe, O., Hamazaki, N., Nagamatsu, G. et al. Reconstitution in vitro of the entire cycle of the mouse female germ line. Nature 539, 299–303 (2016). doi.org/10.1038/nature20104
Please note that The Sheekey Science Show is distinct from Eleanor Sheekey's teaching and research roles at the University of Cambridge. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Sheekey Science Show and guests assume no liability for the application of the information discussed.
Icons in intro; "freepik.com/free-photos-vectors/background"Background vector created by freepik - freepik.com
Fertility declines with age and is impacted by genetics and other lifestyle factors. Understanding early development and gametogenesis (egg and sperm development) could lead to better treatment methods.
In this video we take a look at in vitro gametogenesis - making egg and sperm cells in a dish - using a combination of cellular reprogramming and techniques to turn human induced pluripotent stem cells into precursory egg and sperm. We also take a look at the challenges (epigenetic changes) and how the process has generated fertile offspring in mice.
Find me on Twitter - twitter.com/EleanorSheekey
Support the channel
through PayPal - paypal.me/sheekeyscience?country.x=GB&locale.x=en_GB
through Patreon - patreon.com/TheSheekeyScienceShow
thesheekeyscienceshow.com
TIMESTAMPS:
Intro - 00:00
Gametogenesis - 00:25
Fertility - 01:42
In vitro gametogenesis - 03:35
Thoughts - 07:25
References:
MAMMALIAN IN VITRO GAMETOGENESIS - doi.org/10.1126/science.aaz6830
Yamashiro, C., Sasaki, K., Yokobayashi, S. et al. Generation of human oogonia from induced pluripotent stem cells in culture. Nat Protoc 15, 1560–1583 (2020). doi.org/10.1038/s41596-020-0297-5
Hwang, Y.S., Suzuki, S., Seita, Y. et al. Reconstitution of prospermatogonial specification in vitro from human induced pluripotent stem cells. Nat Commun 11, 5656 (2020). doi.org/10.1038/s41467-020-19350-3
Hikabe, O., Hamazaki, N., Nagamatsu, G. et al. Reconstitution in vitro of the entire cycle of the mouse female germ line. Nature 539, 299–303 (2016). doi.org/10.1038/nature20104
Please note that The Sheekey Science Show is distinct from Eleanor Sheekey's teaching and research roles at the University of Cambridge. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Sheekey Science Show and guests assume no liability for the application of the information discussed.
Icons in intro; "freepik.com/free-photos-vectors/background"Background vector created by freepik - freepik.com
