The Sheekey Science Show | Psychedelics: a trip from mechanism to therapeutic potential? @TheSheekeyScienceShow | Uploaded March 2023 | Updated October 2024, 4 days ago.
"People are trying them. The media is touting them. But scientists say we need to know more about how they work and when they can help." This quote comes from the March Stanford Magazine edition, titled 'Falling for psychedelics'. So is there hope or is it all hype?
Well, in this video we will give an overview to classic psychedelics with some essential neuroanatomy, and then we’ll look at this recent study that has identified a possible therapeutic mechanism that involves activation of pathways involved with dendritic growth. As we’ll come to conclude studies like these are imperative for with providing a foundation with which to guide optimal dosing and to identify individuals who could benefit from psychedelics. and other challenges ahead.
So, firstly, what are psychedelics and why are people excited about them?
Find me on Twitter - twitter.com/EleanorSheekey
Support the channel
through PayPal - paypal.me/sheekeyscience?country.x=GB&locale.x=en_GB
through Patreon - patreon.com/TheSheekeyScienceShow
TIMESTAMPS
Intro - 00:00
What are psychedelics - 00:48
Mechanism of action - 04:00
Hope or hype? - 08:30
References:
Psychedelics promote neuroplasticity through the activation of intracellular 5-HT2A receptors - doi.org/10.1126/science.adf0435
Kwan, A.C., Olson, D.E., Preller, K.H. et al. The neural basis of psychedelic action.
Nat Neurosci 25, 1407–1419 (2022). doi.org/10.1038/s41593-022-01177-4
A High-Resolution In Vivo Atlas of the Human Brain's Serotonin System
Journal of Neuroscience 4 January 2017, 37 (1) 120-128; DOI: 10.1523/JNEUROSCI.2830-16.2016
Single-Dose Psilocybin for a Treatment-Resistant Episode of Major Depression - nejm.org/doi/pdf/10.1056/NEJMoa2206443
science.org/doi/full/10.1126/science.abn5486
Stanford Mag - project-orion-production.s3.amazonaws.com/uploads/issue/182/StanfordMagazine_March2023.pdf
Please note that The Sheekey Science Show is distinct from Eleanor Sheekey's teaching and research roles at the University of Cambridge. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Sheekey Science Show and guests assume no liability for the application of the information discussed.
Icons in intro; "freepik.com/free-photos-vectors/background"Background vector created by freepik - freepik.com
"People are trying them. The media is touting them. But scientists say we need to know more about how they work and when they can help." This quote comes from the March Stanford Magazine edition, titled 'Falling for psychedelics'. So is there hope or is it all hype?
Well, in this video we will give an overview to classic psychedelics with some essential neuroanatomy, and then we’ll look at this recent study that has identified a possible therapeutic mechanism that involves activation of pathways involved with dendritic growth. As we’ll come to conclude studies like these are imperative for with providing a foundation with which to guide optimal dosing and to identify individuals who could benefit from psychedelics. and other challenges ahead.
So, firstly, what are psychedelics and why are people excited about them?
Find me on Twitter - twitter.com/EleanorSheekey
Support the channel
through PayPal - paypal.me/sheekeyscience?country.x=GB&locale.x=en_GB
through Patreon - patreon.com/TheSheekeyScienceShow
TIMESTAMPS
Intro - 00:00
What are psychedelics - 00:48
Mechanism of action - 04:00
Hope or hype? - 08:30
References:
Psychedelics promote neuroplasticity through the activation of intracellular 5-HT2A receptors - doi.org/10.1126/science.adf0435
Kwan, A.C., Olson, D.E., Preller, K.H. et al. The neural basis of psychedelic action.
Nat Neurosci 25, 1407–1419 (2022). doi.org/10.1038/s41593-022-01177-4
A High-Resolution In Vivo Atlas of the Human Brain's Serotonin System
Journal of Neuroscience 4 January 2017, 37 (1) 120-128; DOI: 10.1523/JNEUROSCI.2830-16.2016
Single-Dose Psilocybin for a Treatment-Resistant Episode of Major Depression - nejm.org/doi/pdf/10.1056/NEJMoa2206443
science.org/doi/full/10.1126/science.abn5486
Stanford Mag - project-orion-production.s3.amazonaws.com/uploads/issue/182/StanfordMagazine_March2023.pdf
Please note that The Sheekey Science Show is distinct from Eleanor Sheekey's teaching and research roles at the University of Cambridge. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Sheekey Science Show and guests assume no liability for the application of the information discussed.
Icons in intro; "freepik.com/free-photos-vectors/background"Background vector created by freepik - freepik.com
