Uploaded September 2026 | Updated September 2026, 2 hours ago
You might think Alzheimer's starts in your 70s. Dr. David Perlmutter explains why it begins decades earlier, and how the p-tau 217 blood test flags risk long before symptoms appear. Gary Brecka and Dr. Perlmutter break down microglia, insulin resistance, pre-diabetes, APOE4, homocysteine, vitamin D, creatine and sleep, plus what the POINTER study showed about cognitive decline in metabolically compromised adults.
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Watch the “Ultimate Human Podcast” every Tuesday & Thursday at 9AM EST:
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Timestamps
00:00 – Intro of Show
07:02 – Pre-diabetes & "pre-Alzheimer's"
15:26 – Microglia: brain defenders vs. destroyers
27:30 – Exercise as brain medicine
41:33 – Lifestyle intervention study (Tanzi/Ornish)
44:36 – The POINTER Study
50:29 – Beta-amyloid drugs: risks vs. benefits
1:07:26 – Vitamin D & brain health
1:22:26 – Red light & mitochondrial therapies
1:30:11 – Isolation & brain health
1:35:51 – "What is an Ultimate Human?"
Disclaimer: This podcast is for informational purposes only and does not provide medical advice. It is not intended for diagnosing or treating any health condition. Always consult a licensed healthcare professional before making health or wellness decisions.
Gary Brecka is the owner of Ultimate Human, LLC which operates The Ultimate Human podcast and promotes certain third-party products used by Gary Brecka in his personal health and wellness protocols and daily life and for which Ultimate Human LLC and / or Gary Brecka directly or indirectly holds an economic interest or receives compensation. Accordingly, statements made by Gary Brecka and others (including on The Ultimate Human podcast) may be considered promotional in nature.
You might think Alzheimer's starts in your 70s. Dr. David Perlmutter explains why it begins decades earlier, and how the p-tau 217 blood test flags risk long before symptoms appear. Gary Brecka and Dr. Perlmutter break down microglia, insulin resistance, pre-diabetes, APOE4, homocysteine, vitamin D, creatine and sleep, plus what the POINTER study showed about cognitive decline in metabolically compromised adults.
CLICK HERE TO BECOME GARY’S VIP!: bit.ly/4ai0Xwg
Get Dr. David Perlmutter’s book, “Brain Defenders”: bit.ly/4xvoYtY
Listen to Dr. David Perlmutter on all your favorite platforms!
YouTube: bit.ly/46rZjan
Spotify: bit.ly/4dxPdZl
Apple Podcasts: bit.ly/4dBz19u
Connect with Dr. David Perlmutter
Website: bit.ly/4yEhBBk
YouTube: bit.ly/46rZjan
Instagram: bit.ly/3VgElZH
Facebook: bit.ly/4xvTC6v
TikTok: bit.ly/4xXDcEM
X: bit.ly/4xxJdal
LinkedIn: bit.ly/4yfpNIF
Thank you to our partners
A-GAME: “ULTIMATE15” FOR 15% OFF: bit.ly/4kek1ij
AION: “ULTIMATE10” FOR 10% OFF: bit.ly/4h6KHAD
AIRES: “ULTIMATE20” FOR 20% OFF: bit.ly/4a3Duze
BAJA GOLD: “ULTIMATE10” FOR 10% OFF: bit.ly/3WSBqUa
BODYHEALTH: “ULTIMATE20” FOR 20% OFF: bit.ly/4e5IjsV
COLD LIFE: THE ULTIMATE HUMAN PLUNGE: bit.ly/4eULUKp
CYMBIOTIKA: “BRECKACYM30” FOR 30% OFF: bit.ly/4tjyluP
GENETIC METHYLATION TEST (UK ONLY): bit.ly/48QJJrk
GENETIC TEST (USA ONLY): bit.ly/3Yg1Uk9
GOPUFF: GET YOUR FAVORITE SNACK!: bit.ly/4obIFDC
H2TABS: “ULTIMATE10” FOR 10% OFF: bit.ly/4hMNdgg
HEALF: 10% OFF YOUR ORDER: bit.ly/41HJg6S
PEPTUAL: “TUH10” FOR 10% OFF: bit.ly/4mKxgcn
SNOOZE: LET’S GET TO SLEEP!: bit.ly/4pt1T6V
WHOOP: JOIN & GET 1 FREE MONTH!: bit.ly/3VQ0nzW
Watch the “Ultimate Human Podcast” every Tuesday & Thursday at 9AM EST:
YouTube: bit.ly/3RPQYX8
Podcasts: bit.ly/3RQftU0
Connect with Gary Brecka
Instagram: bit.ly/3RPpnFs
TikTok: bit.ly/4coJ8fo
X: bit.ly/3Opc8tf
Facebook: bit.ly/464VA1H
LinkedIn: bit.ly/4hH7Ri2
Website: bit.ly/4eLDbdU
Merch: bit.ly/4aBpOM1
Newsletter: bit.ly/47ejrws
Ask Gary: bit.ly/3PEAJuG
Timestamps
00:00 – Intro of Show
07:02 – Pre-diabetes & "pre-Alzheimer's"
15:26 – Microglia: brain defenders vs. destroyers
27:30 – Exercise as brain medicine
41:33 – Lifestyle intervention study (Tanzi/Ornish)
44:36 – The POINTER Study
50:29 – Beta-amyloid drugs: risks vs. benefits
1:07:26 – Vitamin D & brain health
1:22:26 – Red light & mitochondrial therapies
1:30:11 – Isolation & brain health
1:35:51 – "What is an Ultimate Human?"
Disclaimer: This podcast is for informational purposes only and does not provide medical advice. It is not intended for diagnosing or treating any health condition. Always consult a licensed healthcare professional before making health or wellness decisions.
Gary Brecka is the owner of Ultimate Human, LLC which operates The Ultimate Human podcast and promotes certain third-party products used by Gary Brecka in his personal health and wellness protocols and daily life and for which Ultimate Human LLC and / or Gary Brecka directly or indirectly holds an economic interest or receives compensation. Accordingly, statements made by Gary Brecka and others (including on The Ultimate Human podcast) may be considered promotional in nature.
