Uploaded February 2026 | Updated September 2026, 3 weeks ago
In this episode, Dr Louise Newson is joined by Dr Mark Horowitz, who is a psychiatrist, researcher and world-leading expert in psychiatric medication withdrawal and deprescribing. Mark is also the lead author of the Maudsley Deprescribing Guidelines and co-founder of Outro Health, the only virtual clinic in the United States offering a clinically validated antidepressant tapering service.
Together, they explore how antidepressants, gabapentinoids and other psychoactive medications became so widely prescribed, and why stopping them is often far more difficult than starting them. The discussion looks closely at what the evidence actually shows about effectiveness, long-term risks, withdrawal effects and suicidality, particularly for women and younger people.
The conversation also examines how hormonal changes, life stressors and social factors are frequently overlooked, leading to the medicalisation of distress that may be a normal response to difficult circumstances.
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Get tickets for my new theatre tour, Breaking the Cycle 👉
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Find out more about Dr. Mark Horowitz's work 👉 markhorowitz.org
Find out more about Outro Health's virtual tapering clinic (US) 👉 outro.com
In this episode, Dr Louise Newson is joined by Dr Mark Horowitz, who is a psychiatrist, researcher and world-leading expert in psychiatric medication withdrawal and deprescribing. Mark is also the lead author of the Maudsley Deprescribing Guidelines and co-founder of Outro Health, the only virtual clinic in the United States offering a clinically validated antidepressant tapering service.
Together, they explore how antidepressants, gabapentinoids and other psychoactive medications became so widely prescribed, and why stopping them is often far more difficult than starting them. The discussion looks closely at what the evidence actually shows about effectiveness, long-term risks, withdrawal effects and suicidality, particularly for women and younger people.
The conversation also examines how hormonal changes, life stressors and social factors are frequently overlooked, leading to the medicalisation of distress that may be a normal response to difficult circumstances.
Want more from the podcast? Sign up to my premium offer: drlouisenewson.co.uk/premium-podcasts
LET'S CONNECT
Subscribe here 👉 youtube.com/@menopause_doctor
Website 👉 drlouisenewson.co.uk
Instagram 👉 / @drlouisenewsonpodcast
Download balance app 👉 / balance-menopause.com/balance-app
LinkedIn 👉 / linkedin.com/in/drlouisenewson
TikTok 👉 / tiktok.com/@drlouisenewson
Spotify 👉 open.spotify.com/show/7dCctfyI9bODGDaFnjfKhg
LEARN MORE
Download my balance app 👉
balance-menopause.com/balance-app
Get tickets for my new theatre tour, Breaking the Cycle 👉
nlp-ltd.com/dr-louise-newson-breaking-the-cycle
Find out more about Dr. Mark Horowitz's work 👉 markhorowitz.org
Find out more about Outro Health's virtual tapering clinic (US) 👉 outro.com
