Perimenopause Brain Fog: How Estrogen and Progesterone Receptors Affect Fear, Stress, and Cognition @DrStacySims
Perimenopause Brain Fog: How Estrogen and Progesterone Receptors Affect Fear, Stress, and Cognition  @DrStacySims
Uploaded May 2026 | Updated September 2026, 2 weeks ago
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Are you in perimenopause and feeling brain fog, mood shifts, or a dulled stress response? This episode explores how declining estrogen and progesterone change receptor activation and sensitivity in the brain, influencing fear, aggression, stress reactivity, and cognition, especially for women approaching or in perimenopause. I break down how interrupted sleep in perimenopause affects the brain’s cleaning process, leading to daytime lapses in concentration. The conversation also covers testosterone decline under stress and why testosterone therapy can help some women, but isn’t automatic or one size fits all.

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Perimenopause Brain Fog: How Estrogen and Progesterone Receptors Affect Fear, Stress, and Cognition

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