Uploaded August 2025 | Updated September 2026, 2 weeks ago

---

Ancient One's Mark is a brand new item introduced in the Epiphany mod for The Binding of Isaac as of the Wave 7.5 update that released on August 9th, 2025. It is one of 18 unlockable milestone items that are acquired by unlocking a set percentage of all of Epiphany's achievements.

Check out Ancient One's Mark at IsaacGuru.com: isaacguru.com/mod/epiphany/item/Ancient_One's_Mark
Download Epiphany: steamcommunity.com/sharedfiles/filedetails/?id=3012430463
Soundtrack used in the video - Old Testament by Excelsior: youtu.be/7XO8K9nDTn0
------------------------------------------------------------------------------
Visit the IsaacGuru website: IsaacGuru.com
Join my Discord: discord.gg/FypTtsshgB
Follow me on Twitter: twitter.com/IsaacGuruYT
Support me on Patreon: patreon.com/IsaacGuru

#thebindingofisaac #tboi #repentance