Uploaded January 2026 | Updated September 2026, 2 weeks ago
As we enter 2026, join us for a discussion of metagenomic next-generation sequencing (mNGS), the innovation revolutionizing how we diagnose and manage infectious and inflammatory diseases. When standard tests fall short, mNGS provides a novel approach to solving diagnostic mysteries. This Grand Rounds will define mNGS and how it fits into clinical practice and public health outbreak surveillance.
Speakers:
Chaz Langelier, MD, PhD, is Associate Professor of Medicine in the Division of Infectious Diseases and Assistant Medical Director of Hospital Epidemiology and Infection Prevention at UCSF Health. Dr. Langelier is an international leader in the application of microbial genomics and host immunoprofiling to understand infectious and inflammatory diseases.
Natasha Spottiswoode, MD, PhD, is Assistant Professor in the UCSF Health Division of Infectious Diseases. Her research sits at the intersection of infectious diseases and critical care, with a focus on advancing and implementing molecular diagnostics and risk stratification approaches based on metagenomic sequencing.
Program:
Bob Wachter: Introduction
1:08-3:40 — Chaz Langelier
3:41-23:43 — Natasha Spottiswoode
23:44-50:22 — Chaz Langelier
50:23-58:08 — Q&A
See previous Medical Grand Rounds:
December 9: Beyond the Scale: Harnessing Anti-Obesity Medications to Treat Obesity and its Complications
• youtu.be/BBY0-1RVvMk
December 2: The Rudi Schmid Lecture: A Cure for Hepatitis C: Now What?
• youtu.be/V4NOnT4qf-A
November 18: Hollander Rounds: A Clinical Problem-Solving Case
• youtu.be/E6zuN1Tm0DQ
October 28: Ethical Cases and Conundrums in Medicine
• youtu.be/QxfKjANDQbw
As we enter 2026, join us for a discussion of metagenomic next-generation sequencing (mNGS), the innovation revolutionizing how we diagnose and manage infectious and inflammatory diseases. When standard tests fall short, mNGS provides a novel approach to solving diagnostic mysteries. This Grand Rounds will define mNGS and how it fits into clinical practice and public health outbreak surveillance.
Speakers:
Chaz Langelier, MD, PhD, is Associate Professor of Medicine in the Division of Infectious Diseases and Assistant Medical Director of Hospital Epidemiology and Infection Prevention at UCSF Health. Dr. Langelier is an international leader in the application of microbial genomics and host immunoprofiling to understand infectious and inflammatory diseases.
Natasha Spottiswoode, MD, PhD, is Assistant Professor in the UCSF Health Division of Infectious Diseases. Her research sits at the intersection of infectious diseases and critical care, with a focus on advancing and implementing molecular diagnostics and risk stratification approaches based on metagenomic sequencing.
Program:
Bob Wachter: Introduction
1:08-3:40 — Chaz Langelier
3:41-23:43 — Natasha Spottiswoode
23:44-50:22 — Chaz Langelier
50:23-58:08 — Q&A
See previous Medical Grand Rounds:
December 9: Beyond the Scale: Harnessing Anti-Obesity Medications to Treat Obesity and its Complications
• youtu.be/BBY0-1RVvMk
December 2: The Rudi Schmid Lecture: A Cure for Hepatitis C: Now What?
• youtu.be/V4NOnT4qf-A
November 18: Hollander Rounds: A Clinical Problem-Solving Case
• youtu.be/E6zuN1Tm0DQ
October 28: Ethical Cases and Conundrums in Medicine
• youtu.be/QxfKjANDQbw
