The Sheekey Science Show | Grape seed extract - new senolytic extends lifespan? @TheSheekeyScienceShow | Uploaded December 2021 | Updated October 2024, 4 days ago.
“Here we show that procyanidin C1 (PCC1), a polyphenolic component of grape seed extract (GSE), increases the healthspan and lifespan of mice through its action on senescent cells.”

So, in this video, we take a look at the research in this recent publication regarding a potential new senolytic compound to add to the others including fisetin and dasatinib & quercetin. As well as my thoughts.. is this the next new senolytic?

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TIMESTAMPS:
Intro - 00:00
Senescent cells - 00:30
New senolytic from grape seed extract - 02:20
Thoughts - 06:10

REFERENCES:
Xu, Q., Fu, Q., Li, Z. et al. The flavonoid procyanidin C1 has senotherapeutic activity and increases lifespan in mice. Nat Metab (2021). doi.org/10.1038/s42255-021-00491-8

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