Kendrew Lecture 2021 pt1 - Using AI to accelerate scientific discovery

MRC Laboratory of Molecular Biology | Kendrew Lecture 2021 pt1 - Using AI to accelerate scientific discovery - Demis Hassabis @LMBCambridge | Uploaded October 2021 | Updated October 2024, 3 hours ago.
MRC Laboratory of Molecular Biology John Kendrew Lecture 2021 part 1
Using AI to accelerate scientific discovery
Speaker: Demis Hassabis, Founder and CEO, DeepMind.

Abstract:
The past decade has seen incredible advances in the field of Artificial Intelligence (AI). DeepMind has been in the vanguard of many of these big breakthroughs, pioneering the development of self-learning systems like AlphaGo, the first program to beat the world champion at the complex game of Go. Games have proven to be a great training ground for developing and testing AI algorithms, but the aim at DeepMind has always been to build general learning systems ultimately capable of solving important problems in the real world. Excitingly, I believe we are on the cusp of a new era in science with AI poised to be a powerful tool for accelerating scientific discovery itself. We recently demonstrated this potential with our AlphaFold system, a solution to the 50-year grand challenge of protein structure prediction, culminating in the release of the most accurate and complete picture of the human proteome.

Read more about the lecture and David's work here: www2.mrc-lmb.cam.ac.uk/john-kendrew-lecture-to-be-given-jointly-by-demis-hassabis-and-john-jumper-from-deepmind

-

About the MRC Laboratory of Molecular Biology (LMB):
The LMB is one of the world's leading research institutes. Discoveries and inventions developed at the LMB, for example DNA sequencing and methods to determine the structure of proteins, have revolutionised all areas of biology. Its scientists work to advance understanding of biological processes at the molecular level. This information will help us to understand the workings of complex systems, such as the immune system and the brain, and solve key problems in human health.

More links:
Official Site: www2.mrc-lmb.cam.ac.uk
Facebook: facebook.com/MRC.LMB
Twitter: twitter.com/MRC_LMB
Instagram: instagram.com/mrc_lmb
LinkedIn: linkedin.com/company/mrc-laboratory-of-molecular-biology
Click here to subscribe to MRC Laboratory of Molecular Biology on YouTube: youtube.com/user/LMBCambridge?sub_confirmation=1

$X-ray Crystallography Structures - Dom Bellini The LMB X-ray Crystallography Facility offers instruments and expertise to help LMB researchers who succeeded in obtaining crystal hits to collect X-ray diffraction data of good enough quality to solve the structure. In this video Dom details the crystallographic project workflow from sample quality, crystallisation, crystal soaking, crystal harvest, to in-house X-ray and synchrotron data collection data, processing and structure validation. The X-ray Crystallography Facility is run by Dom Bellini. Read more about the facility here: https://www2.mrc-lmb.cam.ac.uk/research/scientific-facilities-and-support-services/crystallisation-and-x-ray/ You can find more videos from the LMB 2021 Biophysics Techniques Lecture series here: https://youtube.com/playlist?list=PLQbPquAyEw4fFI5jq8xeGP53PgTSBOc8r Other playlists you might be interested in: Next Generation Biophysics Symposium 2020 - https://www.youtube.com/playlist?list=PLQbPquAyEw4fahTPdotR0NJUpBCm7YjLE Electron Cryo-Microscopy Course 2017 - https://www.youtube.com/playlist?list=PLQbPquAyEw4etKtxyqcvZz4uELPeLDLeF RNA Seq Course - https://youtube.com/playlist?list=PLQbPquAyEw4dn0U FZ-VwKloz8F2E3K5 LMB Crystallography Course 2013 - https://youtube.com/playlist?list=PLQbPquAyEw4f_QBfGRCDW_OkFlocWNMVr About the MRC Laboratory of Molecular Biology (LMB): The LMB is one of the worlds leading research institutes. Discoveries and inventions developed at the LMB, for example DNA sequencing and methods to determine the structure of proteins, have revolutionised all areas of biology. Its scientists work to advance understanding of biological processes at the molecular level. This information will help us to understand the workings of complex systems, such as the immune system and the brain, and solve key problems in human health. More links: Official Site: https://www2.mrc-lmb.cam.ac.uk/ Facebook: https://www.facebook.com/MRC.LMB Twitter: https://twitter.com/MRC_LMB Instagram: https://www.instagram.com/lmbnews/ LinkedIn: https://www.linkedin.com/company/mrc-laboratory-of-molecular-biology Click here to subscribe to MRC Laboratory of Molecular Biology on YouTube: https://www.youtube.com/user/LMBCambridge?sub_confirmation=1$

[TALK 18] Using Proteome Discoverer to Interrogate your Data – Cat Franco

Panel Discussion – Ahead of the Curve: Women Scientists at the LMB

Whats Next For Your Career? LMB + Cambridge Association for Women in Science and Engineering

[TALK 7] Biomolecular Thermodynamics and Calorimetry - Chris Johnson

NGBS2021: Cryo-EM reveals structural insights on DNA Damage Repair- Taiana Maia De Oliveira [TALK 3]

NGBS2022 Talk 8: AlphaFold and its implications for understanding biology- John Jumper

NGBS2020 Biological Phase Separation - Evan Spruijt

$Daniela Rhodes: Aaron, tRNA and chromatin Aaron Klug: A Scientific Retrospective Aaron, tRNA and chromatin by Daniela Rhodes - Aaron Klug was instrumental in revealing the structures of complex biological molecules, from viruses to tRNA, to chromatin and zinc fingers. His most important contribution to scientific research was the development of crystallographic electron microscopy: combining the techniques of electron microscopy and X-ray diffraction to recover three-dimensional structural information from two-dimensional electron micrographs. For this work he was the sole recipient of the 1982 Nobel Prize in Chemistry. - Daniela Rhodes was at the LMB from 1969 to 2011. In 2011 she joined the School of Biological Sciences at the Nanyang Technological University (NTU) in Singapore as Professor and is the Founding Director of the NTU Institute of Structural Biology. Daniela Rhodes started working with Aaron Klug in 1969 as a technician working on the crystal structure of t-RNA and went on to crystallize the nucleosome core in 1976. She did her PhD under the guidance of Aaron working on determining the helical periodicity of DNA in solution to resolve the “linking number paradox”. After obtaining her PhD in 1983 she was appointed Group Leader at the LMB and remained there working in the area of chromosome structural biology until her retirement in 2011. She has provided fundamental insights into the structure, function and regulation of chromatin compaction as well as determining the structure of a number of important protein/DNA complexes involved in transcriptional regulation such as zinc-fingers and nuclear hormone receptors. For the last two decades she has focussed on the structure and function of the protein/DNA complexes that cap and maintain telomeres including the telomerase enzyme. She was one of the first people to suggest a role for DNA G-quadruplexes in biology and provided the first in vivo evidence for their existence and regulation at telomeres. Daniela was Chair of EMBO Council 2009-2011 and was Chair of the HFSPO Council of Scientists until 2020. She is an EMBO member (1996), Fellow of the Royal Society (2007) and member of the Academia Europaea (2011). - About the MRC Laboratory of Molecular Biology (LMB): The LMB is one of the worlds leading research institutes. Discoveries and inventions developed at the LMB, for example DNA sequencing and methods to determine the structure of proteins, have revolutionised all areas of biology. Its scientists work to advance understanding of biological processes at the molecular level. This information will help us to understand the workings of complex systems, such as the immune system and the brain, and solve key problems in human health. More links: Official Site: https://www2.mrc-lmb.cam.ac.uk/ Facebook: https://www.facebook.com/MRC.LMB Twitter: https://twitter.com/MRC_LMB Instagram: https://www.instagram.com/mrc_lmb/ LinkedIn: https://www.linkedin.com/company/mrc-... Click here to subscribe to MRC Laboratory of Molecular Biology on YouTube: https://www.youtube.com/user/LMBCambr...$

[TALK 8] Biosensor Technologies: SPR, BLI and DNA Nanolevers - Stephen McLaughlin