MRC Laboratory of Molecular Biology | NGBS2022 Talk 8: AlphaFold and its implications for understanding biology- John Jumper @LMBCambridge | Uploaded October 2022 | Updated October 2024, 2 hours ago.
AlphaFold and its implications for understanding biology
Speaker: John Jumper, DeepMind, London, UK
Chair: Chris Johnson, MRC Laboratory of Molecular Biology, UK
Co-Chair: Maria Flocco, AstraZeneca, UK
John Jumper describes how AlphaFold predicts highly accurate protein structures from amino acid protein sequence. He highlights the role of the critical assessment in structure prediction (CASP) in stimulating development. He gives an overview of how AlphaFold predicts structures through a process of deep-learning using a neural network. He looks forward to the major challenges in further developments of prediction especially interactomes, conformation states, and the effect of mutation.
Read more about John Jumper and DeepMinds’s work here:
deepmind.com/research
You can find more about the Next Generation Biophysics Symposium 2022 here:
www3.mrc-lmb.cam.ac.uk/sites/nextgen
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About the MRC Laboratory of Molecular Biology (LMB):
The LMB is one of the world's leading research institutes. Discoveries and inventions developed at the LMB, for example DNA sequencing and methods to determine the structure of proteins, have revolutionised all areas of biology. Its scientists work to advance understanding of biological processes at the molecular level. This information will help us to understand the workings of complex systems, such as the immune system and the brain, and solve key problems in human health.
More links:
Official Site: www2.mrc-lmb.cam.ac.uk
Facebook: facebook.com/MRC.LMB
Twitter: twitter.com/MRC_LMB
Instagram: instagram.com/mrc_lmb
LinkedIn: linkedin.com/company/mrc-laboratory-of-molecular-biology
Click here to subscribe to MRC Laboratory of Molecular Biology on YouTube: youtube.com/user/LMBCambridge?sub_confirmation=1
AlphaFold and its implications for understanding biology
Speaker: John Jumper, DeepMind, London, UK
Chair: Chris Johnson, MRC Laboratory of Molecular Biology, UK
Co-Chair: Maria Flocco, AstraZeneca, UK
John Jumper describes how AlphaFold predicts highly accurate protein structures from amino acid protein sequence. He highlights the role of the critical assessment in structure prediction (CASP) in stimulating development. He gives an overview of how AlphaFold predicts structures through a process of deep-learning using a neural network. He looks forward to the major challenges in further developments of prediction especially interactomes, conformation states, and the effect of mutation.
Read more about John Jumper and DeepMinds’s work here:
deepmind.com/research
You can find more about the Next Generation Biophysics Symposium 2022 here:
www3.mrc-lmb.cam.ac.uk/sites/nextgen
--
About the MRC Laboratory of Molecular Biology (LMB):
The LMB is one of the world's leading research institutes. Discoveries and inventions developed at the LMB, for example DNA sequencing and methods to determine the structure of proteins, have revolutionised all areas of biology. Its scientists work to advance understanding of biological processes at the molecular level. This information will help us to understand the workings of complex systems, such as the immune system and the brain, and solve key problems in human health.
More links:
Official Site: www2.mrc-lmb.cam.ac.uk
Facebook: facebook.com/MRC.LMB
Twitter: twitter.com/MRC_LMB
Instagram: instagram.com/mrc_lmb
LinkedIn: linkedin.com/company/mrc-laboratory-of-molecular-biology
Click here to subscribe to MRC Laboratory of Molecular Biology on YouTube: youtube.com/user/LMBCambridge?sub_confirmation=1
![[TALK 8] Biosensor Technologies: SPR, BLI and DNA Nanolevers - Stephen McLaughlin](https://i.ytimg.com/vi/xGhChdQhbQA/hqdefault.jpg "[TALK 8] Biosensor Technologies: SPR, BLI and DNA Nanolevers - Stephen McLaughlin
Biosensor Technologies: SPR, BLI and DNA Nanolevers
Speaker: Stephen McLaughlin, MRC Laboratory of Molecular Biology, UK
The LMB Biophysics Facility houses a wide range of state-of-the-art and in-house built instruments that enable the molecular characterisation of macromolecular size, shape, mass, stability, binding affinity, dynamics and interaction kinetics.
The facility is primarily intended for hands-on research by students, postdocs, and group leaders, who prepare samples and make measurements. Biophysics supports users in advice on experimental techniques and results, training and in collaborative research.
In this video, Stephen explains how different biosensors technologies can be used to understand the binding affinity and kinetics of biomolecular interactions. He covers the basis of the different detection methods, immobilisation strategies, experiment set-ups and how data can be analysed. Several applications of each technique are shown.
The Biophysics Facility is headed by Chris Johnson, supported by Stephen McLaughlin.
Read more about the facility here: https://www2.mrc-lmb.cam.ac.uk/research/scientific-facilities-and-support-services/biophysics/
You can find more videos from the LMB 2022 Biophysics Techniques Lecture series here: https://www.youtube.com/playlist?list=PLQbPquAyEw4dQ3zOLrdS1eF_KJJbUUyBx
About the MRC Laboratory of Molecular Biology (LMB):
The LMB is one of the worlds leading research institutes. Discoveries and inventions developed at the LMB, for example DNA sequencing and methods to determine the structure of proteins, have revolutionised all areas of biology. Its scientists work to advance understanding of biological processes at the molecular level. This information will help us to understand the workings of complex systems, such as the immune system and the brain, and solve key problems in human health.
More links:
Official Site: https://www2.mrc-lmb.cam.ac.uk/
Facebook: https://www.facebook.com/MRC.LMB
Twitter: https://twitter.com/MRC_LMB
Instagram: https://www.instagram.com/mrc_lmb/
LinkedIn: https://www.linkedin.com/company/mrc-laboratory-of-molecular-biology
Click here to subscribe to MRC Laboratory of Molecular Biology on YouTube: https://www.youtube.com/user/LMBCambridge?sub_confirmation=1")
![[TALK 21] AlphaFold: Use and Applications – Sami Chaaban](https://i.ytimg.com/vi/yJKfn6rvHmg/hqdefault.jpg "[TALK 21] AlphaFold: Use and Applications – Sami Chaaban
AlphaFold: Uses and Applications
Speaker: Sami Chaaban, MRC Laboratory of Molecular Biology, UK
2024 Introduction to Biophysical Techniques
In this video Sami gives an introduction the protein structure prediction software AlphaFold. He briefly describes how it works. He details the key outputs of the program and how they can be used to assess the reliability of the predicted structures. In addition to single proteins, Sami describes how protein complexes can be modelled using AlphaFold Multimer. He shows how users can use AlphaFold for their proteins by either downloading from databases of already preformed predictions or how to run predictions on their own sequences. He highlights the potential issues in predictions that users need to beware of. Finally, he illustrates the applications of AlphaFold with examples from his own scientific research and other projects within the LMB.
To learn more about the use of artificial intelligence (AI) in scientific research you can watch the Kendrew Lecture 2021 pt1 given by Demis Hassabis from DeepMind here: https://www.youtube.com/watch?v=sm-VkgVX-2o&t=16s
To learn about the development of AlphaFold you can watch the Kendrew Lecture 2021 pt2 given by John Jumper, the AlphaFold lead at DeepMind here: https://www.youtube.com/watch?v=jTO6odQNp90&t=2552s
Discover more about Sami’s research in the Andrew Carter lab at the LMB here: https://www2.mrc-lmb.cam.ac.uk/groups/cartera
Read more about software developed at the LMB here: https://www2.mrc-lmb.cam.ac.uk/research/locally-developed-software/
You can find more videos from the LMB 2024 Biophysics Techniques Lecture series here:
https://www.youtube.com/playlist?list=PLQbPquAyEw4d39XeoMFR1G9UlAr1t7Qoz
About the MRC Laboratory of Molecular Biology (LMB):
The LMB is one of the worlds leading research institutes. Discoveries and inventions developed at the LMB, for example DNA sequencing and methods to determine the structure of proteins, have revolutionised all areas of biology. Our scientists work to advance understanding of biological processes at the molecular level. This information will help us to understand the workings of complex systems, such as the immune system and the brain, and solve key problems in human health.
More links:
Official Site: https://www2.mrc-lmb.cam.ac.uk/
Facebook: https://www.facebook.com/MRC.LMB
X/Twitter: https://twitter.com/MRC_LMB
Instagram: https://www.instagram.com/mrc_lmb/
LinkedIn: https://www.linkedin.com/company/mrc-laboratory-of-molecular-biology
Click here to subscribe to MRC Laboratory of Molecular Biology on YouTube: https://www.youtube.com/user/LMBCambridge?sub_confirmation=1")
![[TALK 2] Image Processing for Light Microscopy - Jérôme Boulanger](https://i.ytimg.com/vi/yL99QQlmYD4/hqdefault.jpg "[TALK 2] Image Processing for Light Microscopy - Jérôme Boulanger
Image Processing for Light Microscopy
Speaker: Jérôme Boulanger, MRC Laboratory of Molecular Biology, UK
The LMB Light Microscopy Facility supports a diverse range of light microscopy imaging techniques within the LMB including single molecule fluorescence applications, high content screening, confocal microscopy, and intravital imaging using multiphoton excitation. In addition to commercial systems, the facility is building new instruments such as a light sheet microscope. The facility is primarily intended for hands-on research by students, postdocs, and group leaders, who prepare specimens, and operate the microscopes. Light Microscopy supports users in advice, training, assistance in imaging processing, and through the development of custom analysis software tailored to a specific application.
This video gives an overview of why we need to process the image and what the workflow process is using software. It covers topics such as filtering, sources of noise, de-noising, image deconvolution, image segmentation, object tracking, and co-localisation.
The Light Microscopy Facility is headed by Nick Barry, an optical physicist and specialist in light microscopy.
Read more about the facility here: https://www2.mrc-lmb.cam.ac.uk/research/scientific-facilities-and-support-services/light-microscopy/
You can find more videos from the LMB 2022 Biophysics Techniques Lecture series here: https://youtube.com/playlist?list=PLQbPquAyEw4dQ3zOLrdS1eF_KJJbUUyBx
About the MRC Laboratory of Molecular Biology (LMB):
The LMB is one of the worlds leading research institutes. Discoveries and inventions developed at the LMB, for example DNA sequencing and methods to determine the structure of proteins, have revolutionised all areas of biology. Its scientists work to advance understanding of biological processes at the molecular level. This information will help us to understand the workings of complex systems, such as the immune system and the brain, and solve key problems in human health.
More links:
Official Site: https://www2.mrc-lmb.cam.ac.uk/
Facebook: https://www.facebook.com/MRC.LMB
Twitter: https://twitter.com/MRC_LMB
Instagram: https://www.instagram.com/mrc_lmb/
LinkedIn: https://www.linkedin.com/company/mrc-laboratory-of-molecular-biology
Click here to subscribe to MRC Laboratory of Molecular Biology on YouTube: https://www.youtube.com/user/LMBCambridge?sub_confirmation=1")
![[TALK 22] Biophysics in Drug Discovery: Chris Stubbs & Geoff Holdgate](https://i.ytimg.com/vi/ytPx-gYTcI0/hqdefault.jpg "[TALK 22] Biophysics in Drug Discovery: Chris Stubbs & Geoff Holdgate
Biophysics in Drug Discovery
Speakers: Chris Stubbs & Geoff Holdgate, AstraZeneca, UK
2024 Introduction to Biophysical Techniques
In this video, Geoff Holdgate gives an overview of drug discovery at AstraZeneca. He discusses why it is so difficult to make drugs and what chemical properties are optimal for drugs. He explains how biophysics fits within the drug programme operation model and what questions it can answer at different stages of the process. In the second part of the talk, Chris Stubbs describes the biophysical tools used at AstraZeneca. He details examples of how these tools have answered critical questions such as reagent quality control, hit identification and validation. He shows how different techniques can overcome an apparent potency limit highlighting their strengths and weaknesses. He lastly looks at using biophysical techniques to understand molecular glues.
Read more about AstraZeneca’s work here:
https://www.astrazeneca.com/r-d.html
You can find more videos from the LMB 2024 Biophysics Techniques Lecture series here:
https://www.youtube.com/playlist?list=PLQbPquAyEw4d39XeoMFR1G9UlAr1t7Qoz
About the MRC Laboratory of Molecular Biology (LMB):
The LMB is one of the worlds leading research institutes. Discoveries and inventions developed at the LMB, for example DNA sequencing and methods to determine the structure of proteins, have revolutionised all areas of biology. Our scientists work to advance understanding of biological processes at the molecular level. This information will help us to understand the workings of complex systems, such as the immune system and the brain, and solve key problems in human health.
More links:
Official Site: https://www2.mrc-lmb.cam.ac.uk/
Facebook: https://www.facebook.com/MRC.LMB
X/Twitter: https://twitter.com/MRC_LMB
Instagram: https://www.instagram.com/mrc_lmb/
LinkedIn: https://www.linkedin.com/company/mrc-laboratory-of-molecular-biology
Click here to subscribe to MRC Laboratory of Molecular Biology on YouTube: https://www.youtube.com/user/LMBCambridge?sub_confirmation=1")
