Uploaded August 2022 | Updated September 2026, 1 week ago
Immune Imprinting - Mechanism and Discussion
Let's understand the mechanism of immune imprinting, or antigenic imprinting, or original antigenic sin (OAS), or Hoskins effect. Or, in case of innate arm reprogramming.
If you like this content and want more, I am doing a special lifetime membership offer. Click here:
drbeen.com/yt-special-p
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Buy me a coffee :-) buymeacoffee.com/DrMobeenSyed
Become my patron: patreon.com/mobeensyed?fan_landing=true
PayPal: paypal.me/mobeensyed?locale.x=en_US
My substack: mobeensyedmd.substack.com
#drbeen #koolbeens #COVID
Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.
URL list from Wednesday, Aug. 3 2022
Book reference:
FIGURE 14.1 The gastrointestinal immune system.
Abbas, Abul K.; Lichtman, Andrew H.; Pillai, Shiv. Cellular and Molecular Immunology E-Book (p. 315). Elsevier Health Sciences. Kindle Edition.
FIGURE 14.3 Homing properties of intestinal lymphocytes.The
Effector lymphocytes that are generated in the GALT and mesenteric lymph nodes are imprinted with selective integrin- and chemokine receptor– dependent gut-homing properties, and they circulate from the blood back into the lamina propria of the gut
Abbas, Abul K.; Lichtman, Andrew H.; Pillai, Shiv. Cellular and Molecular Immunology E-Book (p. 320). Elsevier Health Sciences. Kindle Edition.
The gut-homing phenotype of IgA-producing B cells and effector T cells is imprinted by DCs through the action of retinoic acid during the process of T cell activation
Abbas, Abul K.; Lichtman, Andrew H.; Pillai, Shiv. Cellular and Molecular Immunology E-Book (p. 321). Elsevier Health Sciences. Kindle Edition.
FIGURE 14.10 Homing properties of skin lymphocytes.The
Abbas, Abul K.; Lichtman, Andrew H.; Pillai, Shiv. Cellular and Molecular Immunology E-Book (p. 331). Elsevier Health Sciences. Kindle Edition.
Original Antigenic Sin: How First Exposure Shapes Lifelong Anti–Influenza Virus Immune Responses | The Journal of Immunology
jimmunol.org/content/202/2/335
Imprinting of the immune system by the microbiota early in life | Mucosal Immunology
nature.com/articles/s41385-020-0257-y
Original antigenic sin - Wikipedia
en.wikipedia.org/wiki/Original_antigenic_sin
Antigenic imprinting in SARS‐CoV‐2 - Reincke - 2022 - Clinical and Translational Medicine - Wiley Online Library
onlinelibrary.wiley.com/doi/full/10.1002/ctm2.923
Cryo-EM structure of the SARS-CoV-2 Omicron spike - PMC
ncbi.nlm.nih.gov/pmc/articles/PMC8818377
Autoantibody discovery across monogenic, acquired, and COVID19-associated autoimmunity with scalable PhIP-Seq - PMC
ncbi.nlm.nih.gov/pmc/articles/PMC8963698
Heterologous infection and vaccination shapes immunity against SARS-CoV-2 variants | Science
science.org/doi/10.1126/science.abm0811
Immune imprinting: A key issue for COVID-19 vaccines
medicalnewstoday.com/articles/what-immune-imprinting-means-for-the-future-of-covid-19-vaccines
Immune imprinting, breadth of variant recognition, and germinal center response in human SARS-CoV-2 infection and vaccination - PubMed
pubmed.ncbi.nlm.nih.gov/35148837
Immune imprinting, breadth of variant recognition, and germinal center response in human SARS-CoV-2 infection and vaccination - PMC
ncbi.nlm.nih.gov/pmc/articles/PMC8786601
Immunological imprinting of the antibody response in COVID-19 patients | Nature Communications
nature.com/articles/s41467-021-23977-1
Trained Innate Immunity, Epigenetics, and Covid-19 | NEJM
nejm.org/doi/full/10.1056/NEJMcibr2011679
Recall of pre-existing cross-reactive B cell memory following Omicron BA.1 breakthrough infection - PMC
ncbi.nlm.nih.gov/pmc/articles/PMC9097882
Immune imprinting causes varied patterns of protection against COVID-19 variants | Imperial News | Imperial College London
imperial.ac.uk/news/232396/immune-imprinting-causes-varied-patterns-protection
Immune Imprinting - Mechanism and Discussion
Let's understand the mechanism of immune imprinting, or antigenic imprinting, or original antigenic sin (OAS), or Hoskins effect. Or, in case of innate arm reprogramming.
If you like this content and want more, I am doing a special lifetime membership offer. Click here:
drbeen.com/yt-special-p
Want to support this work?:
Buy me a coffee :-) buymeacoffee.com/DrMobeenSyed
Become my patron: patreon.com/mobeensyed?fan_landing=true
PayPal: paypal.me/mobeensyed?locale.x=en_US
My substack: mobeensyedmd.substack.com
#drbeen #koolbeens #COVID
Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.
URL list from Wednesday, Aug. 3 2022
Book reference:
FIGURE 14.1 The gastrointestinal immune system.
Abbas, Abul K.; Lichtman, Andrew H.; Pillai, Shiv. Cellular and Molecular Immunology E-Book (p. 315). Elsevier Health Sciences. Kindle Edition.
FIGURE 14.3 Homing properties of intestinal lymphocytes.The
Effector lymphocytes that are generated in the GALT and mesenteric lymph nodes are imprinted with selective integrin- and chemokine receptor– dependent gut-homing properties, and they circulate from the blood back into the lamina propria of the gut
Abbas, Abul K.; Lichtman, Andrew H.; Pillai, Shiv. Cellular and Molecular Immunology E-Book (p. 320). Elsevier Health Sciences. Kindle Edition.
The gut-homing phenotype of IgA-producing B cells and effector T cells is imprinted by DCs through the action of retinoic acid during the process of T cell activation
Abbas, Abul K.; Lichtman, Andrew H.; Pillai, Shiv. Cellular and Molecular Immunology E-Book (p. 321). Elsevier Health Sciences. Kindle Edition.
FIGURE 14.10 Homing properties of skin lymphocytes.The
Abbas, Abul K.; Lichtman, Andrew H.; Pillai, Shiv. Cellular and Molecular Immunology E-Book (p. 331). Elsevier Health Sciences. Kindle Edition.
Original Antigenic Sin: How First Exposure Shapes Lifelong Anti–Influenza Virus Immune Responses | The Journal of Immunology
jimmunol.org/content/202/2/335
Imprinting of the immune system by the microbiota early in life | Mucosal Immunology
nature.com/articles/s41385-020-0257-y
Original antigenic sin - Wikipedia
en.wikipedia.org/wiki/Original_antigenic_sin
Antigenic imprinting in SARS‐CoV‐2 - Reincke - 2022 - Clinical and Translational Medicine - Wiley Online Library
onlinelibrary.wiley.com/doi/full/10.1002/ctm2.923
Cryo-EM structure of the SARS-CoV-2 Omicron spike - PMC
ncbi.nlm.nih.gov/pmc/articles/PMC8818377
Autoantibody discovery across monogenic, acquired, and COVID19-associated autoimmunity with scalable PhIP-Seq - PMC
ncbi.nlm.nih.gov/pmc/articles/PMC8963698
Heterologous infection and vaccination shapes immunity against SARS-CoV-2 variants | Science
science.org/doi/10.1126/science.abm0811
Immune imprinting: A key issue for COVID-19 vaccines
medicalnewstoday.com/articles/what-immune-imprinting-means-for-the-future-of-covid-19-vaccines
Immune imprinting, breadth of variant recognition, and germinal center response in human SARS-CoV-2 infection and vaccination - PubMed
pubmed.ncbi.nlm.nih.gov/35148837
Immune imprinting, breadth of variant recognition, and germinal center response in human SARS-CoV-2 infection and vaccination - PMC
ncbi.nlm.nih.gov/pmc/articles/PMC8786601
Immunological imprinting of the antibody response in COVID-19 patients | Nature Communications
nature.com/articles/s41467-021-23977-1
Trained Innate Immunity, Epigenetics, and Covid-19 | NEJM
nejm.org/doi/full/10.1056/NEJMcibr2011679
Recall of pre-existing cross-reactive B cell memory following Omicron BA.1 breakthrough infection - PMC
ncbi.nlm.nih.gov/pmc/articles/PMC9097882
Immune imprinting causes varied patterns of protection against COVID-19 variants | Imperial News | Imperial College London
imperial.ac.uk/news/232396/immune-imprinting-causes-varied-patterns-protection
