Uploaded June 2026 | Updated September 2026, 2 weeks ago
DNA data storage is moving from a fascinating research topic toward something that can eventually live alongside enterprise storage in real data centers, but the leap is not only about chemistry or sequencing speed. It is about manageability, interoperability, and standardized APIs that let operators monitor, provision, and troubleshoot systems at scale.
In this conversation, Vincent Franceschini, co-chair of the SNIA DNA Data Storage Alliance and Richelle Ahlvers, long-time chair of the SNIA Storage Management Community and primary author of the SNIA Swordfish® specification, connect the dots between a new storage medium and the standards-based management that makes it operable at scale.
Archives are turning “active” because of AI, and long-term preservation is back in the spotlight. DNA data can become a durable data center technology if standards are built early, models are shared openly, and the community aligns on terminology, lifecycle operations, and monitoring so tomorrow’s archives remain readable and manageable for decades.
SNIA is an industry organization that develops global standards and delivers vendor-neutral education on technologies related to data. In these interviews, SNIA experts on data cover a wide range of topics on both established and emerging technologies.
About SNIA:
• Website (https://www.snia.org)
• Educational Library (snia.org/library)
• X/Twitter (twitter.com/SNIA)
• LinkedIn (linkedin.com/company/snia/)
DNA data storage is moving from a fascinating research topic toward something that can eventually live alongside enterprise storage in real data centers, but the leap is not only about chemistry or sequencing speed. It is about manageability, interoperability, and standardized APIs that let operators monitor, provision, and troubleshoot systems at scale.
In this conversation, Vincent Franceschini, co-chair of the SNIA DNA Data Storage Alliance and Richelle Ahlvers, long-time chair of the SNIA Storage Management Community and primary author of the SNIA Swordfish® specification, connect the dots between a new storage medium and the standards-based management that makes it operable at scale.
Archives are turning “active” because of AI, and long-term preservation is back in the spotlight. DNA data can become a durable data center technology if standards are built early, models are shared openly, and the community aligns on terminology, lifecycle operations, and monitoring so tomorrow’s archives remain readable and manageable for decades.
SNIA is an industry organization that develops global standards and delivers vendor-neutral education on technologies related to data. In these interviews, SNIA experts on data cover a wide range of topics on both established and emerging technologies.
About SNIA:
• Website (https://www.snia.org)
• Educational Library (snia.org/library)
• X/Twitter (twitter.com/SNIA)
• LinkedIn (linkedin.com/company/snia/)









![Nanopore sequencing of synthetic libraries of RNA oligonucleotides
Photolithography is one of the very approaches that allow for the synthesis of nucleic acid microarrays in situ, and characteristic aspects of in situ microarray synthesis are high-throughput and high-density, delivering several hundreds of thousands of unique sequences in a single run and on a single, small surface (Figure 1). Microarray synthesis has traditionally focused on the preparation of DNA microarrays to obtain complex DNA libraries. These have been used in the context of DNA data storage, gene synthesis and other nanotechnology applications [1]. Recently, our group has shown that photolithography is amenable to prepare RNA microarrays as well, at identical throughput and density [2]. It remains the only available chemical approach that can deliver complex synthetic RNA libraries with total control on the sequence. RNA microarrays can be used to interrogate the sequence preference of enzymes and RNA-binding proteins, but they are also ideally poised to generate RNA libraries for off-array applications. We can produce pools of RNA sequences between 75 and 100-nt in length which can be sequenced directly by Nanopore sequencing without any intermediate purification step [3]. Our photolithography platform also allows for the introduction of biologically relevant base modifications, of which m6A, 5mC and inosine are already available and preliminary data shows that m6A can be accurately basecalled. Simultaneously, nanopore sequencing data returns crucial information on the synthetic error-rate of RNA photolithography. This talk will focus on presenting the technology of RNA photolithography and on describing how RNA libraries can be prepared and sequenced.
Presented by
Jory Lietard, University of Vienna
This is a presentation from the 2026 Storage and Computing with DNA Conference.
· Learn More about the SNIA DNA Data Storage Alliance: https://www.snia.org/groups/snia-dna-technology-affiliate
· SNIA Educational Library: https://snia.org/library
· X: https://twitter.com/SNIA
· LinkedIn: https://linkedin.com/company/snia/ Nanopore sequencing of synthetic libraries of RNA oligonucleotides](https://i.ytimg.com/vi/VNJYQbz7MTY/mqdefault.jpg)
