Uploaded June 2026 | Updated September 2026, 2 weeks ago

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The mechanism behind hot flashes and the new pharmacology that blocks it. Dr. Jordan Feigenbaum walks the Avis 2015 SWAN data on VMS duration, the KNDy neuron mechanism, and the SKYLIGHT 1 and 2 trials of fezolinetant. Dr. Austin Baraki walks who actually gets this medication in clinic.

Timestamps:
• 00:00 7.4 years of hot flashes
• 02:00 The KNDy mechanism: from autopsy to drug target
• 04:00 SKYLIGHT 1 and 2: fezolinetant trials
• 05:40 Austin: who actually gets fezolinetant
• 07:00 Elinzanetant: the newer agent

Resources
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• Avis NE et al. JAMA Intern Med, 2015. pubmed.ncbi.nlm.nih.gov/25686030
• Lederman S et al. SKYLIGHT 1, Lancet, 2023. pubmed.ncbi.nlm.nih.gov/36924778
• Johnson KA et al. SKYLIGHT 2, JCEM, 2023. pubmed.ncbi.nlm.nih.gov/37410020
• Pinkerton JV et al. OASIS elinzanetant, JAMA, 2024. pubmed.ncbi.nlm.nih.gov/39163087