Hantzsch Dihydropyridine Synthesis Mechanism | Organic Chemistry @OrganicMechanismsChannel

Uploaded January 2023 | Updated September 2026, 2 weeks ago

The Hantzsch pyridine synthesis involves the condensation of two equivalents of a β-dicarbonyl compound, one equivalent of an aldehyde and one equivalent of ammonia. The immediate result from this three-component coupling, 1,4-dihydropyridine, is easily oxidized to a fully substituted pyridine. Saponification and decarboxylation of the 3,5-ester substituents leads to a 2,4,6-trisubstituted pyridine.

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$Hantzsch Dihydropyridine Synthesis Mechanism | Organic Chemistry The Hantzsch pyridine synthesis involves the condensation of two equivalents of a β-dicarbonyl compound, one equivalent of an aldehyde and one equivalent of ammonia. The immediate result from this three-component coupling, 1,4-dihydropyridine, is easily oxidized to a fully substituted pyridine. Saponification and decarboxylation of the 3,5-ester substituents leads to a 2,4,6-trisubstituted pyridine. Music: His Last Summer – Infraction$

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