Boekelheide Reaction Mechanism | Organic Chemistry @OrganicMechanismsChannel

Uploaded March 2022 | Updated September 2026, 1 week ago

The mechanism for a Boekelheide reaction which involves the treatment of 2-methylpyridine N-oxide with trifluoroacetic anhydride, or acetic, anhydride to produce 2-hydroxymethylpyridine.

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Boekelheide Reaction Mechanism | Organic Chemistry