Uploaded February 2024 | Updated September 2026, 7 hours ago
The nerd super duo is back at it again. This time, Dr. Trexler plays Sherlock and Dr. Helms plays Watson in a discussion of how overtraining syndrome, metabolic adaptation, relative energy deficiency in sport, exercise energy compensation, body fat regulation, and more, are both distinct from one another, yet are all also closely related. Surprisingly, it took a couple meat head bodybuilders to notice the shared characteristics and overlap between these separate concepts. That’s precisely because bodybuilders are crazy enough to go through a process that often results in their simultaneous occurrence! Listen in to find out what these concepts are, when they intersect as well as diverge, how you can identify which you or or your clients are experiencing, and what to do about it.
00:00 A (kind of) synced up intro and an appearance from Omar
02:04 A brainstorming session on metabolism
massresearchreview.com
Omar Isuf - Why You Shouldn’t Try To Be “Shredded” youtube.com/watch?v=GmlGt49Oi1I
strongerbyscience.com/stay-shredded
08:30 Low energy availability and the female athlete triad
Areta 2021 Low energy availability: history, definition and evidence of its endocrine, metabolic and physiological effects in prospective studies in females and males pubmed.ncbi.nlm.nih.gov/33095376
23:20 Energy availability and body fat
Loucks 2003 Energy availability, not body fatness, regulates reproductive function in women pubmed.ncbi.nlm.nih.gov/12882481
29:15 Relative Energy Deficiency in Sport and the drivers of metabolic adaptation
Burke 2023 Mapping the complexities of Relative Energy Deficiency in Sport (REDs): development of a physiological model by a subgroup of the International Olympic Committee (IOC) Consensus on REDs pubmed.ncbi.nlm.nih.gov/37752007
Mountjoy 2023 2023 International Olympic Committee's (IOC) consensus statement on Relative Energy Deficiency in Sport (REDs) pubmed.ncbi.nlm.nih.gov/37752011
Hackney 2005 Testosterone and endurance exercise: development of the "exercise-hypogonadal male condition pubmed.ncbi.nlm.nih.gov/16268050
Hackney 2020 Hypogonadism in Exercising Males: Dysfunction or Adaptive-Regulatory Adjustment? pubmed.ncbi.nlm.nih.gov/32082255
48:07 Overtraining syndrome
Stellingwerff 2021 Overtraining Syndrome (OTS) and Relative Energy Deficiency in Sport (RED-S): Shared Pathways, Symptoms and Complexities pubmed.ncbi.nlm.nih.gov/34181189
Iron Culture Ep. 149- Overreaching, Overtraining, and Insufficient Recovery: Everything You Need To Know youtube.com/watch?v=ZxohJX_F-XY
55:08 Energy constraint and compensation
Dolan 2023 Energy constraint and compensation: Insights from endurance athletes pubmed.ncbi.nlm.nih.gov/37557979
1:05:13 A practical spin: bringing all the information together
1:20:07 Closing out with a shoutout to our sponsor: The RED-S calorie-free food van
The nerd super duo is back at it again. This time, Dr. Trexler plays Sherlock and Dr. Helms plays Watson in a discussion of how overtraining syndrome, metabolic adaptation, relative energy deficiency in sport, exercise energy compensation, body fat regulation, and more, are both distinct from one another, yet are all also closely related. Surprisingly, it took a couple meat head bodybuilders to notice the shared characteristics and overlap between these separate concepts. That’s precisely because bodybuilders are crazy enough to go through a process that often results in their simultaneous occurrence! Listen in to find out what these concepts are, when they intersect as well as diverge, how you can identify which you or or your clients are experiencing, and what to do about it.
00:00 A (kind of) synced up intro and an appearance from Omar
02:04 A brainstorming session on metabolism
massresearchreview.com
Omar Isuf - Why You Shouldn’t Try To Be “Shredded” youtube.com/watch?v=GmlGt49Oi1I
strongerbyscience.com/stay-shredded
08:30 Low energy availability and the female athlete triad
Areta 2021 Low energy availability: history, definition and evidence of its endocrine, metabolic and physiological effects in prospective studies in females and males pubmed.ncbi.nlm.nih.gov/33095376
23:20 Energy availability and body fat
Loucks 2003 Energy availability, not body fatness, regulates reproductive function in women pubmed.ncbi.nlm.nih.gov/12882481
29:15 Relative Energy Deficiency in Sport and the drivers of metabolic adaptation
Burke 2023 Mapping the complexities of Relative Energy Deficiency in Sport (REDs): development of a physiological model by a subgroup of the International Olympic Committee (IOC) Consensus on REDs pubmed.ncbi.nlm.nih.gov/37752007
Mountjoy 2023 2023 International Olympic Committee's (IOC) consensus statement on Relative Energy Deficiency in Sport (REDs) pubmed.ncbi.nlm.nih.gov/37752011
Hackney 2005 Testosterone and endurance exercise: development of the "exercise-hypogonadal male condition pubmed.ncbi.nlm.nih.gov/16268050
Hackney 2020 Hypogonadism in Exercising Males: Dysfunction or Adaptive-Regulatory Adjustment? pubmed.ncbi.nlm.nih.gov/32082255
48:07 Overtraining syndrome
Stellingwerff 2021 Overtraining Syndrome (OTS) and Relative Energy Deficiency in Sport (RED-S): Shared Pathways, Symptoms and Complexities pubmed.ncbi.nlm.nih.gov/34181189
Iron Culture Ep. 149- Overreaching, Overtraining, and Insufficient Recovery: Everything You Need To Know youtube.com/watch?v=ZxohJX_F-XY
55:08 Energy constraint and compensation
Dolan 2023 Energy constraint and compensation: Insights from endurance athletes pubmed.ncbi.nlm.nih.gov/37557979
1:05:13 A practical spin: bringing all the information together
1:20:07 Closing out with a shoutout to our sponsor: The RED-S calorie-free food van
