Reactions | Can Science Make Less Addictive Opioids? @ACSReactions | Uploaded 3 years ago | Updated 3 minutes ago
Will we ever have painkillers as good as opioids, but without the risk of addiction and overdose?
#opioids #heroin #opioidcrisis
You might also like:
What Happens When You Overdose?:
youtu.be/xLSz3wEgwJ8
Why Are Synthetic Drugs So Dangerous?:
youtube.com/watch?v=83gIiBD365E
The Top 5 Strangest Poisons That Can Kill You:
youtu.be/4hQ0G0GaYR8
Can You Take Expired Drugs?:
youtu.be/aT4qzgEQr-Y
What is Addiction?:
youtu.be/C6I3CHhBGeQ
Credits:
Executive Producers:
George Zaidan
Hilary Hudson
Producers:
Andrew Sobey
Elaine Seward
Writer/Host:
Sam Jones, PhD
Scientific consultants:
Michelle Boucher, PhD
Kelly Dunn, PhD
Leila Duman, PhD
Kim Janda, PhD
Sources:
Frederich Serturner
pubmed.ncbi.nlm.nih.gov/1786314
Opioid toxicity
ncbi.nlm.nih.gov/books/NBK431077
Opioid overdoses--world stats https://www.who.int/news-room/fact-sheets/detail/opioid-overdose#:~:text=difficulties%20with%20breathing.-,Worldwide%2C%20about%200.5%20million%20deaths%20are%20attributable%20to%20drug%20use,of%20opioid%20overdose%20in%202017
Opioid death rates in the US
drugabuse.gov/drug-topics/trends-statistics/overdose-death-rates#:~:text=Opioid%2Dinvolved%20overdose%20deaths%20rose,in%202018%20with%2046%2C802%20deaths.
Inside the Story of America’s 19th-Century Opiate Addiction
smithsonianmag.com/history/inside-story-americas-19th-century-opiate-addiction-180967673
Abuse-deterrent opioids
pubs.acs.org/doi/10.1021/cen-09545-cover2
NIH solicits research into vaccines that protect against opioid use genengnews.com/insights/nih-solicits-research-into-vaccines-to-protect-against-opioid-use
Vaccines against addictive drugs push forward despite past failures
cen.acs.org/articles/96/i8/Vaccines-against-addictive-drugs-push.html?utm_source=ACSMembership&utm_medium=Webinar&utm_campaign=CEN
Looking beyond opioids for safer pain relief
cen.acs.org/articles/95/i45/chemists-responding-opioid-epidemic.html?utm_source=ACSMembership&utm_medium=Webinar&utm_campaign=CEN
Opioid abuse timeline (FDA)
fda.gov/drugs/information-drug-class/timeline-selected-fda-activities-and-significant-events-addressing-opioid-misuse-and-abuse
Overdose death rates
drugabuse.gov/drug-topics/trends-statistics/overdose-death-rates#:~:text=Opioid%2Dinvolved%20overdose%20deaths%20rose,in%202018%20with%2046%2C802%20deaths.
Prostaglandins
chem.libretexts.org/Bookshelves/Biological_Chemistry/Supplemental_Modules_(Biological_Chemistry)/Lipids/Fatty_Acids/Prostaglandins#:~:text=Prostaglandin%20Structure-,Prostaglandins%20are%20unsaturated%20carboxylic%20acids%2C%20consisting%20of%20of%20a%2020,two%2C%20or%20three%20double%20bonds.&text=A%20typical%20structure%20is%20on%20the%20left%20graphic.
God’s Own Medicine
skepticalinquirer.org/2017/03/gods-own-medicine
Heroin
pubchem.ncbi.nlm.nih.gov/compound/Heroin
Ibuprofen
pubchem.ncbi.nlm.nih.gov/compound/Ibuprofen
Oxycodone
pubchem.ncbi.nlm.nih.gov/compound/Oxycodone
Heroin chapter
sciencedirect.com/science/article/pii/B0123693977004568
Structure of ibuprofen bound to COX-2
ncbi.nlm.nih.gov/pmc/articles/PMC4276492
Use of Oxycodone in Pain Management
ncbi.nlm.nih.gov/pmc/articles/PMC4018705/#:~:text=Oxycodone%20is%20an%20analgesic%20opioid,market%20in%201996%20(2).
Overcoming opioids: The quest for less addictive drugs
statnews.com/2017/04/17/opioids-quest-less-addictive-drugs
Rats prefer sugar to heroin
pubmed.ncbi.nlm.nih.gov/28645064
NIDA heroin info
drugabuse.gov/sites/default/files/heroinrrs_11_14.pdf
Heroin History
hazelden.org/HAZ_MEDIA/7988_heroin.pdf
Frontline PBS: Opium throughout history pbs.org/wgbh/pages/frontline/shows/heroin/etc/history.html
The Ongoing Opioid Prescription Epidemic: Historical Context
ncbi.nlm.nih.gov/pmc/articles/PMC4940677
Heroin’s Addiction’s Fraught History
theatlantic.com/health/archive/2014/02/heroin-addictions-fraught-history/284001
Heroin Prescription and History
core.ac.uk/reader/189542775?utm_source=linkout
Addiction medications
americanaddictioncenters.org/addiction-medications
Opiate history
michaelshouse.com/opiate-rehab/history-of-opiates
Death Tolls
cdc.gov/drugoverdose/epidemic/index.html
Overdose Increases
cdc.gov/media/releases/2020/p1218-overdose-deaths-covid-19.html
Etanercept
ncbi.nlm.nih.gov/books/NBK545252
Produced by the American Chemical Society. Join the American Chemical Society! http://bit.ly/Join_acsmembership
Will we ever have painkillers as good as opioids, but without the risk of addiction and overdose?
#opioids #heroin #opioidcrisis
You might also like:
What Happens When You Overdose?:
youtu.be/xLSz3wEgwJ8
Why Are Synthetic Drugs So Dangerous?:
youtube.com/watch?v=83gIiBD365E
The Top 5 Strangest Poisons That Can Kill You:
youtu.be/4hQ0G0GaYR8
Can You Take Expired Drugs?:
youtu.be/aT4qzgEQr-Y
What is Addiction?:
youtu.be/C6I3CHhBGeQ
Credits:
Executive Producers:
George Zaidan
Hilary Hudson
Producers:
Andrew Sobey
Elaine Seward
Writer/Host:
Sam Jones, PhD
Scientific consultants:
Michelle Boucher, PhD
Kelly Dunn, PhD
Leila Duman, PhD
Kim Janda, PhD
Sources:
Frederich Serturner
pubmed.ncbi.nlm.nih.gov/1786314
Opioid toxicity
ncbi.nlm.nih.gov/books/NBK431077
Opioid overdoses--world stats https://www.who.int/news-room/fact-sheets/detail/opioid-overdose#:~:text=difficulties%20with%20breathing.-,Worldwide%2C%20about%200.5%20million%20deaths%20are%20attributable%20to%20drug%20use,of%20opioid%20overdose%20in%202017
Opioid death rates in the US
drugabuse.gov/drug-topics/trends-statistics/overdose-death-rates#:~:text=Opioid%2Dinvolved%20overdose%20deaths%20rose,in%202018%20with%2046%2C802%20deaths.
Inside the Story of America’s 19th-Century Opiate Addiction
smithsonianmag.com/history/inside-story-americas-19th-century-opiate-addiction-180967673
Abuse-deterrent opioids
pubs.acs.org/doi/10.1021/cen-09545-cover2
NIH solicits research into vaccines that protect against opioid use genengnews.com/insights/nih-solicits-research-into-vaccines-to-protect-against-opioid-use
Vaccines against addictive drugs push forward despite past failures
cen.acs.org/articles/96/i8/Vaccines-against-addictive-drugs-push.html?utm_source=ACSMembership&utm_medium=Webinar&utm_campaign=CEN
Looking beyond opioids for safer pain relief
cen.acs.org/articles/95/i45/chemists-responding-opioid-epidemic.html?utm_source=ACSMembership&utm_medium=Webinar&utm_campaign=CEN
Opioid abuse timeline (FDA)
fda.gov/drugs/information-drug-class/timeline-selected-fda-activities-and-significant-events-addressing-opioid-misuse-and-abuse
Overdose death rates
drugabuse.gov/drug-topics/trends-statistics/overdose-death-rates#:~:text=Opioid%2Dinvolved%20overdose%20deaths%20rose,in%202018%20with%2046%2C802%20deaths.
Prostaglandins
chem.libretexts.org/Bookshelves/Biological_Chemistry/Supplemental_Modules_(Biological_Chemistry)/Lipids/Fatty_Acids/Prostaglandins#:~:text=Prostaglandin%20Structure-,Prostaglandins%20are%20unsaturated%20carboxylic%20acids%2C%20consisting%20of%20of%20a%2020,two%2C%20or%20three%20double%20bonds.&text=A%20typical%20structure%20is%20on%20the%20left%20graphic.
God’s Own Medicine
skepticalinquirer.org/2017/03/gods-own-medicine
Heroin
pubchem.ncbi.nlm.nih.gov/compound/Heroin
Ibuprofen
pubchem.ncbi.nlm.nih.gov/compound/Ibuprofen
Oxycodone
pubchem.ncbi.nlm.nih.gov/compound/Oxycodone
Heroin chapter
sciencedirect.com/science/article/pii/B0123693977004568
Structure of ibuprofen bound to COX-2
ncbi.nlm.nih.gov/pmc/articles/PMC4276492
Use of Oxycodone in Pain Management
ncbi.nlm.nih.gov/pmc/articles/PMC4018705/#:~:text=Oxycodone%20is%20an%20analgesic%20opioid,market%20in%201996%20(2).
Overcoming opioids: The quest for less addictive drugs
statnews.com/2017/04/17/opioids-quest-less-addictive-drugs
Rats prefer sugar to heroin
pubmed.ncbi.nlm.nih.gov/28645064
NIDA heroin info
drugabuse.gov/sites/default/files/heroinrrs_11_14.pdf
Heroin History
hazelden.org/HAZ_MEDIA/7988_heroin.pdf
Frontline PBS: Opium throughout history pbs.org/wgbh/pages/frontline/shows/heroin/etc/history.html
The Ongoing Opioid Prescription Epidemic: Historical Context
ncbi.nlm.nih.gov/pmc/articles/PMC4940677
Heroin’s Addiction’s Fraught History
theatlantic.com/health/archive/2014/02/heroin-addictions-fraught-history/284001
Heroin Prescription and History
core.ac.uk/reader/189542775?utm_source=linkout
Addiction medications
americanaddictioncenters.org/addiction-medications
Opiate history
michaelshouse.com/opiate-rehab/history-of-opiates
Death Tolls
cdc.gov/drugoverdose/epidemic/index.html
Overdose Increases
cdc.gov/media/releases/2020/p1218-overdose-deaths-covid-19.html
Etanercept
ncbi.nlm.nih.gov/books/NBK545252
Produced by the American Chemical Society. Join the American Chemical Society! http://bit.ly/Join_acsmembership
