How Do Antiviral Drugs Work? @ACSReactions

Reactions | How Do Antiviral Drugs Work? @ACSReactions | Uploaded 4 years ago | Updated 1 hour ago
Antiviral drugs could help us fight the new coronavirus, but we don’t currently have a highly potent and effective antiviral that cures COVID-19. Why not? We called a few virologists to find out.

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Gilead's remdesivir gets emergency use authorization based on preliminary data in COVID-19
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Cell studies suggest some repurposed drugs could block replication of SARS-CoV-2
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How big pharma firms are quietly collaborating on new coronavirus antivirals
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Could an Existing Vaccine Stop the Coronavirus Pandemic?
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How Much Do Cloth Masks Protect You From Getting the Coronavirus?
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Coronavirus Vaccine: Where Are We and What's Next?:
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Credits:
Executive Producers:
George Zaidan
Hilary Hudson

Producers:
Andrew Sobey
Elaine Seward

Writer/Host:
George Zaidan

Scientific consultants:
Rebecca Dutch, PhD
Vincent Racaniello, PhD
Paul Offit, PhD
Lelia Duman, PhD
Brianne Raccor, PhD

Special Thanks:
Lisa Jarvis
Julia Price Radice

#coronavirus
#cure
#remdesivir

Sources:
All interventional SARS-CoV-2 trials registered on clinicaltrials.gov
clinicaltrials.gov/ct2/results?cond=COVID-19&recrs=b&recrs=a&recrs=f&recrs=d&recrs=e&age_v=&gndr=&type=Intr&rslt=&Search=Apply

Antivirals Lecture
youtube.com/watch?v=w4N63NY_jDc

Pulmonary critical care series on COVID treatment
pulmccm.org/review-articles/an-illustrated-primer-on-covid-19-therapy-part-1
pulmccm.org/review-articles/an-illustrated-primer-on-covid-19-therapy-part-2

Coronavirus therapeutics
cdc.gov/coronavirus/2019-ncov/hcp/therapeutic-options.html

Remdesivir
nytimes.com/2020/05/01/health/coronavirus-remdesivir.html

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$Does Sugar Cause Diabetes? If you have diabetes, you have way too much sugar in your bloodstream. So does eating a lot of sugar cause it? #diabetes #bloodsugar #insulin You might also like: Are Food Calories Bull-oney?: https://youtu.be/ahvE5kuWcps How Much Candy Would Kill You?: https://youtu.be/RNOycTzN-fg Whats the Difference Between Sugar and High Fructose Corn Syrup?: https://youtu.be/fXMvregmU1g Do Ketogenic Diets Really Work?: https://youtu.be/nU07pvKK7nw How to Stay Awake Without Caffeine: https://youtu.be/SvEQBURrPow Credits: Executive Producers: George Zaidan Hilary Hudson Producers: Andrew Sobey Elaine Seward Writer/Host: Sam Jones, PhD Scientific consultants: Thomas Delong, PhD Leila Duman, PhD Peter Havel, DVM, PhD Katie Page, MD Brianne Raccor, PhD Kimber Stanhope, PhD Sources: Consumption of sugar-sweetened beverages, artificially sweetened beverages, and fruit juice and incidence of type 2 diabetes: systematic review, meta-analysis, and estimation of population attributable fraction https://www.bmj.com/content/351/bmj.h3576 Sugar-Sweetened Beverages and Risk of Metabolic Syndrome and Type 2 Diabetes https://care.diabetesjournals.org/content/33/11/2477 A Prospective Study of Sugar Intake and Risk of Type 2 Diabetes in Women https://care.diabetesjournals.org/content/diacare/26/4/1008.full.pdf Gestational diabetes https://www.diabetes.org/diabetes/gestational-diabetes/how-will-this-impact-my-baby Type 2 diabetes https://www.cdc.gov/diabetes/basics/type2.html Diabetes https://www.mayoclinic.org/diseases-conditions/diabetes/symptoms-causes/syc-20371444 Visceral fat and diabetes https://www.diabetes.co.uk/body/visceral-fat.html Gestational diabetes https://www.mayoclinic.org/diseases-conditions/gestational-diabetes/symptoms-causes/syc-20355339 Symptoms & Causes of Diabetes https://www.niddk.nih.gov/health-information/diabetes/overview/symptoms-causes Sugar and diabetes https://www.diabetes.org.uk/guide-to-diabetes/enjoy-food/eating-with-diabetes/food-groups/sugar-and-diabetes Does eating too much sugar cause diabetes? https://chicagocaresdpp.org/does-eating-too-much-sugar-cause-diabetes/ Why too much sugar is bad for you https://www.healthline.com/nutrition/too-much-sugar Does sugar cause diabetes? https://www.healthline.com/nutrition/does-sugar-cause-diabetes#bottom-line Belly fat promotes diabetes https://www.cuimc.columbia.edu/news/belly-fat-promotes-diabetes-under-orders-liver#:~:text=The%20fat%20that%20builds%20up,determining%20what%20causes%20the%20inflammation. Sugar and diabetes https://www.pcrm.org/news/blog/does-sugar-cause-diabetes Reiser, S., et al., Isocaloric exchange of dietary starch and sucrose in humans. II. Effect on fasting blood insulin, glucose, and glucagon and on insulin and glucose response to a sucrose load. Am J Clin Nutr, 1979. 32(11): p. 2206-16. Hallfrisch, J., et al., Effects of dietary fructose on plasma glucose and hormone responses in normal and hyperinsulinemic men. J Nutr, 1983. 113(9): p. 1819-26. Reiser, S., et al., Serum insulin and glucose in hyperinsulinemic subjects fed three different levels of sucrose. Am J Clin Nutr, 1981. 34(11): p. 2348-58. Schwarz, J.M., et al., Effect of a High-Fructose Weight-Maintaining Diet on Lipogenesis and Liver Fat. J Clin Endocrinol Metab, 2015. 100(6): p. 2434-42. Aeberli I, Hochuli M, Gerber PA, Sze L, Murer SB, Tappy L, Spinas GA, Berneis K. Moderate amounts of fructose consumption impair insulin sensitivity in healthy young men: a randomized controlled trial. Diabetes Care. 2013 Jan;36(1):150-6. Stanhope KL, Schwarz JM, Keim NL, Griffen SC, Bremer AA, Graham JL, Hatcher B, Cox CL, Dyachenko A, Zhang W, McGahan JP, Seibert A, Krauss RM, Chiu S, Schaefer EJ, Ai M, Otokozawa S, Nakajima K, Nakano T, Beysen C, Hellerstein MK, Berglund L, Havel PJ. Consuming fructose-sweetened, not glucose-sweetened, beverages increases visceral adiposity and lipids and decreases insulin sensitivity in overweight/obese humans. J Clin Invest. 2009 May;119(5):1322-34.$

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