Uploaded October 2017 | Updated September 2026, 2 hours ago
The term midlife crisis was introduced in 1965 and refers to a deep self-examination that occurs in middle-aged individuals, typically between 45 and 64 years old. This self-examination highlights how a person’s increasing age and inevitable mortality creates feelings of anxiety and depression. In this episode, Washington University neurosurgeons at Barnes-Jewish Hospital discuss brain activity during a midlife crisis including neuroplasticity and BDNF (brain-derived neurotrophic factor).
For a full list of video podcasts, visit: barnesjewish.org/The-Brain-Coffee-Podcast.
Subscribe to the Barnes-Jewish Hospital YouTube Channel: youtube.com/user/BarnesJewishHospital
Connect with Barnes-Jewish Hospital:
- Facebook: facebook.com/barnesjewishhospital
- Twitter: twitter.com/Barnesjewish
The term midlife crisis was introduced in 1965 and refers to a deep self-examination that occurs in middle-aged individuals, typically between 45 and 64 years old. This self-examination highlights how a person’s increasing age and inevitable mortality creates feelings of anxiety and depression. In this episode, Washington University neurosurgeons at Barnes-Jewish Hospital discuss brain activity during a midlife crisis including neuroplasticity and BDNF (brain-derived neurotrophic factor).
For a full list of video podcasts, visit: barnesjewish.org/The-Brain-Coffee-Podcast.
Subscribe to the Barnes-Jewish Hospital YouTube Channel: youtube.com/user/BarnesJewishHospital
Connect with Barnes-Jewish Hospital:
- Facebook: facebook.com/barnesjewishhospital
- Twitter: twitter.com/Barnesjewish










