Beliefs About Genetics Can Influence Biological Outcomes @hubermanlab

Uploaded May 2025 | Updated September 2026, 2 weeks ago

Being told you have really good or bad genes for a given sport or endeavor shapes the outcome in the direction you expect. Genes definitely constrain outcomes, especially at the extremes (think height and professional basketball) but genetic knowledge can often help or hinder.

Beliefs About Genetics Can Influence Biological Outcomes

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$Understanding & Conquering Depression | Huberman Lab Essentials In this Huberman Lab Essentials episode, I explore major depression, including its underlying biology and discuss science-based approaches to alleviate symptoms and improve mood. I describe the wide-ranging symptoms of depression and explain how key neurotransmitters, hormones, stress, genetics and inflammation contribute to its development and persistence. I also cover treatment options, from traditional classes of antidepressant medications to emerging therapies such as ketamine and psilocybin. Finally, I highlight lifestyle-based tools, including exercise, supplementation and dietary strategies that can help manage depressive symptoms and promote mental well-being. Episode show notes: https://go.hubermanlab.com/Tg17gmA Huberman Lab Essentials are short episodes focused on essential science and protocol takeaways from past full-length Huberman Lab episodes. Watch the full-length episode: https://youtu.be/Xu1FMCxoEFc Watch more Huberman Lab Essentials episodes: https://youtube.com/playlist?list=PLPNW_gerXa4OGNy1yE-W9IX-tPu-tJa7S *Follow Huberman Lab* Instagram: https://www.instagram.com/hubermanlab Threads: https://www.threads.net/@hubermanlab X: https://twitter.com/hubermanlab Facebook: https://www.facebook.com/hubermanlab TikTok: https://www.tiktok.com/@hubermanlab LinkedIn: https://www.linkedin.com/in/andrew-huberman Website: https://www.hubermanlab.com Newsletter: https://www.hubermanlab.com/newsletter *Timestamps* 00:00:00 Major Depression 00:01:10 Depression Symptoms 00:06:14 Pharmaceuticals for Depression, SSRIs; Norepinephrine, Dopamine & Serotonin 00:13:14 Thyroid Hormone, Cortisol, Stress & Depression, Menstrual Cycle, Genetics 00:16:23 Increase Norepinephrine, Tools: Deliberate Cold Exposure & Exercise 00:18:43 Chronic Inflammation & Depression, Tools: Omega-3s (EPA) & Exercise 00:23:52 Tool: Creatine Monohydrate Supplementation & Improving Depression 00:25:32 Novel Depression Therapies, Ketamine, Psilocybin 00:30:41 Ketogenic Diet & Refractory Depression, GABA 00:33:09 Recap & Key Takeaways Disclaimer & Disclosures: https://www.hubermanlab.com/disclaimer$

Andrew Huberman |

Beliefs About Genetics Can Influence Biological Outcomes