Uploaded February 2026 | Updated September 2026, 2 weeks ago

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Dr. Tony Wyss-Coray, PhD, is a professor of neurology at Stanford School of Medicine and Director of the Phil and Penny Knight Initiative for Brain Resilience who is discovering factors present in young blood and in exercised blood that can improve brain, heart, and other organ health. We discuss how different organs age at different rates and how to accurately measure biological aging. We also discuss the specific proteins found in blood when we are young and that are increased by things such as exercise, sunlight exposure, short-term fasting, specific foods, and social connection that can significantly increase vitality, restore youthful functioning of the brain and body, and potentially increase lifespan.

Show notes: go.hubermanlab.com/U67koOl

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Dr. Tony Wyss-Coray
Stanford cademic profile: https://med.stanford.edu/profiles/tony-wyss-coray
Lab website: https://web.stanford.edu/group/twclab/cgi-bin
Publications: scholar.google.com/citations?user=huboyZcAAAAJ&hl=en
TED talk: ted.com/speakers/tony_wyss_coray
X: https://x.com/wysscoray
LinkedIn: linkedin.com/in/tony-wyss-coray-91592010

Timestamps
00:00:00 Tony Wyss-Coray
00:03:00 Young vs Old Animals, Age-Related Disease
00:06:35 Blood Biomarkers, Young vs Old Humans, Alzheimer's Disease
00:12:50 Sponsors: David & LMNT
00:15:28 'Young Blood' Factors, Rejuvenation, Stem Cells
00:20:15 Blood Banking; Dracula
00:23:10 Rates of Aging in Organs, Age Gap & Disease Risk; Risk Profiles & Therapies
00:33:02 NAD Levels & Aging, NMN Supplements
00:36:44 Vitality vs Longevity; Periods of Accelerated Aging
00:43:17 Sponsors: AG1 & Roka
00:45:22 Sunlight; Youthful Blood Factors, Exercise & Brain Function, Fasting
00:51:25 Exercise, Injury & Inflammation
00:56:18 Pro-health Factors, Klotho, GDF11, Stem Cell Injection Risk
01:02:35 Platelet-Rich Plasma (PRP); Exosomes
01:05:43 Smoking, EMFs, Plastics, Long-Term Accumulation, Fresh Foods, Organic Food
01:11:28 Sponsor: Function
01:13:16 Intermittent Fasting, Long-Term Fasting, Snacking
01:19:07 Sleep; Cerebrospinal Fluid (CSF) Factors & Cognitive Function
01:24:44 Exercise Type & Longevity; Exercise Enjoyment
01:32:02 Lifestyle Factors & Alzheimer's Risk; Cognitive Exercise; Chocolate
01:37:05 Alcohol & Social Connection; US vs European Food Culture
01:40:50 Deliberate Deep Breathing; Wearables, Sunlight & Artificial Light
01:49:13 Future Projects
01:56:40 Zero-Cost Support, YouTube, Spotify & Apple Follow, Reviews & Feedback, Sponsors, Protocols Book, Social Media, Neural Network Newsletter

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