Uploaded June 2026 | Updated September 2026, 2 weeks ago

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_In loving memory of Nolan Williams (1982-2025):_ ⁠⁠https://stan.md/3Qle2zp⁠⁠

In this Huberman Lab Essentials episode, my guest is Dr. Nolan Williams, MD, a triple board-certified psychiatrist and neurologist. We discuss cutting-edge treatments for depression and post-traumatic stress disorder (PTSD), including transcranial magnetic stimulation, neuromodulation, and psychedelic-assisted therapies. We also discuss the neurobiology and therapeutic potential of specific psychedelic compounds, including psilocybin, MDMA, ibogaine, and ayahuasca.

Show notes: go.hubermanlab.com/KWwu7p6

Watch more Huberman Lab Essentials: youtube.com/playlist?list=PLPNW_gerXa4OGNy1yE-W9IX-tPu-tJa7S&si=a1_sA7rUT-fE0OM5

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Timestamps
00:00:00 Nolan Williams
00:00:26 Depression
00:02:51 Heart & Mind Connection, Transcranial Magnetic Stimulation (TMS)
00:05:21 TMS for Depression
00:07:52 SSRIs & Chemical imbalance, TMS, Psychedelics
00:13:51 Psilocybin, MDMA, Trauma
00:16:48 MDMA Clinical Trials & PTSD; Psilocybin & Depression
00:18:46 Psilocybin, Brain Connectivity & Depression
00:21:07 Ibogaine, Empathy; Psychedelic Breakthrough & Risk
00:27:44 Ayahuasca, Behavior Change, Prisoners
00:31:54 Stanford Accelerated Intelligent Neuromodulation Therapy (SAINT)
00:35:56 Acknowledgements

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