Uploaded October 2018 | Updated September 2026, 1 week ago
"Good" medical trials are placebo-controlled, but when might it be immoral to even perform such an experiment?
-Links for the Curious-
The Ethics of Placebo-controlled Trials: Methodological Justifications (Millum & Grady, 2013) _ ncbi.nlm.nih.gov/pmc/articles/PMC3844122
The ethics of the placebo in clinical practice (Lichtenberg et al, 2002) - jme.bmj.com/content/30/6/551
The ethics of using placebo in randomised controlled trials: a case study of a Plasmodium vivax antirelapse trial - bmcmedethics.biomedcentral.com/articles/10.1186/s12910-018-0259-4
"The Morality of A/B Testing" - techcrunch.com/2014/06/29/ethics-in-a-data-driven-world
"What really helps the poor?" - aeon.co/essays/can-randomised-controlled-trials-test-whether-poverty-relief-works
"Good" medical trials are placebo-controlled, but when might it be immoral to even perform such an experiment?
-Links for the Curious-
The Ethics of Placebo-controlled Trials: Methodological Justifications (Millum & Grady, 2013) _ ncbi.nlm.nih.gov/pmc/articles/PMC3844122
The ethics of the placebo in clinical practice (Lichtenberg et al, 2002) - jme.bmj.com/content/30/6/551
The ethics of using placebo in randomised controlled trials: a case study of a Plasmodium vivax antirelapse trial - bmcmedethics.biomedcentral.com/articles/10.1186/s12910-018-0259-4
"The Morality of A/B Testing" - techcrunch.com/2014/06/29/ethics-in-a-data-driven-world
"What really helps the poor?" - aeon.co/essays/can-randomised-controlled-trials-test-whether-poverty-relief-works


![208. How Complex Systems Fail
Engineering disasters often highlight how bad decisions can wreak havoc, but Dr. Richard Cooks model of complex systems & how they fail paints a different picture.
- Links for the Curious -
How Complex Systems Fail (Cook, 2000) - https://how.complexsystems.fail/
Behind Human Error: Cognitive Systems, Computers and Hindsight (Cook, 1994) - https://apps.dtic.mil/dtic/tr/fulltext/u2/a492127.pdf
Normal Accidents (Perrow, 1984) - http://geo.unibuc.ro/dm/Documents/[Charles_Perrow]_Normal_Accidents.pdf
Velocity 2012: Richard Cook, How Complex Systems Fail - https://www.youtube.com/watch?v=2S0k12uZR14
Velocity NY 2013: Richard Cook, Resilience In Complex Adaptive Systems - https://www.youtube.com/watch?v=PGLYEDpNu60
Flying Astronauts to Space Is Never Routine (Koren, 2020) - https://www.theatlantic.com/science/archive/2020/11/spacex-nasa-astronauts-crew-launch/617112/
Well Theres Your Problem 8: Three Mile Island - https://www.youtube.com/watch?v=Sm5p2K9eW9o
Well Theres Your Problem 4: The Hyatt Regency Walkway Collapse - https://www.youtube.com/watch?v=Hw2t0MOGnVc
Well Theres Your Problem 12A: The Boeing 737 Max - https://www.youtube.com/watch?v=yvM6vaZKKm4
Well Theres Your Problem 14: The Quebec Bridge - https://www.youtube.com/watch?v=SjOduiPSF1Q
THUNK 161: 13 Reasons Why & Compatibilism - https://www.youtube.com/watch?v=ngQ7Dh9-NFM
THUNK 199: FMEA - Dodging Disaster - https://www.youtube.com/watch?v z2s9Ornp6U
Climbing Accident Reports: How (and Why) to Read Them (Kirby, courtesy of Angus Smith!) - http://www.alpineinstitute.com/articles/expert-tips/climbing-accident-reports-how-(and-why)-to-read-them/
Funny how many problems boil down to People need to be less shitty to one another.
-Ulfoolius
Rest in peace, man. You will be missed. 208. How Complex Systems Fail](https://i.ytimg.com/vi/dPFw2ckWZyY/mqdefault.jpg)







