The Sheekey Science Show | Why I study p53. (the world's coolest protein) @TheSheekeyScienceShow | Uploaded June 2021 | Updated October 2024, 4 days ago.
Did you know i study p53?
Well I do. *
So what is it and why is it the world's coolest protein?
Well, maybe it isn't the world's coolest protein, but p53 is a important protein in human cells. p53 is a stress-activated transcription factor which means it can bind DNA and influence the expression of other genes. What genes it activates and when p53 does this dictates the downstream cellular responses to p53 activation. This includes cell cycle arrest, apoptosis, cellular senescence, DNA repair and alterations in metabolism.
It is for these reasons that p53 is regarded a tumour suppressor. However, though maybe not surprisingly, p53 is the most commonly mutated gene seen in human cancers. It's the mutated version of p53 that I do most of my studies on. You see, a subset of these mutations are called missense mutations, whereby there is a single amino acid substitution. These means the full length p53 protein is still produced but the amino acid change renders the protein malfunctional since it can no longer bind DNA. Given that at least (most likely) one cell in your body has a mutated p53 allele, it seems interesting to understand how the presence of mutant-p53 in "normal" cells may cause changes making a cell more prone to tumorigenesis...or not!
*this was meant to be read as "Well yes I do study p53" as opposed to "Well I know I study p53"
TIMESTAMPS:
Intro - 00:00
p53 is - 01:15
live vs. death (senescence vs. apoptosis) - 03:30
mutant-p53 - 06:30
interventions to destabilise mut-p53 - 09:20
REFERENCES:
My brain
Baar et al., 2017, Cell 169, 132–147
March 23, 2017 ª 2017 Elsevier Inc.
dx.doi.org/10.1016/j.cell.2017.02.031 Targeted Apoptosis of Senescent Cells Restores
Tissue Homeostasis in Response to Chemotoxicity
and Aging
Life and Death Decision-Making by p53 and Implications for Cancer Immunotherapy doi.org/10.1016/j.trecan.2020.10.005
p53 and Tumor Suppression: It Takes a Network
doi.org/10.1016/j.tcb.2020.12.011
Check out @LifeXtenShow 's latest video youtube.com/watch?v=eXmGbe9czek
Icons in intro; "freepik.com/free-photos-vectors/background"Background vector created by freepik - freepik.com
Did you know i study p53?
Well I do. *
So what is it and why is it the world's coolest protein?
Well, maybe it isn't the world's coolest protein, but p53 is a important protein in human cells. p53 is a stress-activated transcription factor which means it can bind DNA and influence the expression of other genes. What genes it activates and when p53 does this dictates the downstream cellular responses to p53 activation. This includes cell cycle arrest, apoptosis, cellular senescence, DNA repair and alterations in metabolism.
It is for these reasons that p53 is regarded a tumour suppressor. However, though maybe not surprisingly, p53 is the most commonly mutated gene seen in human cancers. It's the mutated version of p53 that I do most of my studies on. You see, a subset of these mutations are called missense mutations, whereby there is a single amino acid substitution. These means the full length p53 protein is still produced but the amino acid change renders the protein malfunctional since it can no longer bind DNA. Given that at least (most likely) one cell in your body has a mutated p53 allele, it seems interesting to understand how the presence of mutant-p53 in "normal" cells may cause changes making a cell more prone to tumorigenesis...or not!
*this was meant to be read as "Well yes I do study p53" as opposed to "Well I know I study p53"
TIMESTAMPS:
Intro - 00:00
p53 is - 01:15
live vs. death (senescence vs. apoptosis) - 03:30
mutant-p53 - 06:30
interventions to destabilise mut-p53 - 09:20
REFERENCES:
My brain
Baar et al., 2017, Cell 169, 132–147
March 23, 2017 ª 2017 Elsevier Inc.
dx.doi.org/10.1016/j.cell.2017.02.031 Targeted Apoptosis of Senescent Cells Restores
Tissue Homeostasis in Response to Chemotoxicity
and Aging
Life and Death Decision-Making by p53 and Implications for Cancer Immunotherapy doi.org/10.1016/j.trecan.2020.10.005
p53 and Tumor Suppression: It Takes a Network
doi.org/10.1016/j.tcb.2020.12.011
Check out @LifeXtenShow 's latest video youtube.com/watch?v=eXmGbe9czek
Icons in intro; "freepik.com/free-photos-vectors/background"Background vector created by freepik - freepik.com
