Uploaded August 2026 | Updated September 2026, 1 week ago
For additional nuances, all the references and early access to content like this, see the associated newsletter: open.substack.com/pub/staycuriousmetabolism/p/how-to-quietly-grow-your-brain-in?r=40ekz2&utm_campaign=post&utm_medium=web&showWelcomeOnShare=true
5-Amino-1-MQ Letter: staycuriousmetabolism.substack.com/p/the-metabolic-leak-that-might-be?r=40ekz2
Dihexa Letter: open.substack.com/pub/staycuriousmetabolism/p/dihexa-the-brain-boosting-peptide?r=40ekz2&utm_campaign=post&utm_medium=web&showWelcomeOnShare=true
If you want to try either 5-Amino-1-MQ or Dihexa, the company I personally use for these is Wingspan. I’ve vetted them and the meet all my criteria, including having high regulatory standards, cGMP certification, and they came recommended by a trusted colleague.
Try 5-Amino-1MQ → try.gotwingspan.com/norwitz5Amino1MQ
Try Dihexa → try.gotwingspan.com/norwitzDihexa
Discount code is “StayCurious”
Warning: These aren’t cheap products. I mention them for those who have the means and enjoy responsible self-experimentation.
Chapters
0:00 – Grow Your Brain in 30 Minutes Per Day?
2:03 – The Twin Study That Made Me Rethink Leg Day
6:23 – The BDNF-Irisin Axis
9:52 – How Muscles Maintain Healthy Blood Sugar
11:47 – Muscles, Brain, and Brain Blood Flow
12:13 – The Muscle-NAD-Brain Axis
13:17 – Practical Protocols
17:00 – 5-Amino-1-MQ: Plugging the Metabolic Leak
17:47 – Dihexa: 10,000,000 Times Stronger Than BDNF?
Description
Could your next leg workout do more than build muscle? In this video, we explore fascinating research showing that greater leg strength is associated with better cognitive aging, larger brain volume, and reduced cognitive decline—even among identical twins. You'll learn how your muscles act as endocrine organs, releasing signaling molecules that directly influence brain health, memory, metabolism, and resilience.
We'll unpack the science behind BDNF, irisin, insulin sensitivity, blood flow, and NAD+, then translate the research into practical training recommendations you can start using today. Finally, we'll discuss evidence-based supplements including creatine, 5-amino-1MQ, and Dihexa, and where they fit (and don't fit) alongside the fundamentals of exercise, sleep, and metabolic health.
For additional nuance, scientific references, and deeper dives into the mechanisms discussed in this video, check out the accompanying StayCurious letter linked above.
#BrainHealth #LegDay #Exercise #StrengthTraining #Longevity #HealthyAging #Neuroscience #Brain #Cognition #Memory #BDNF #Irisin #Muscle #MuscleHealth #Fitness #ResistanceTraining #Aging #Alzheimers #DementiaPrevention #MetabolicHealth #InsulinSensitivity #BloodSugar #NAD #Mitochondria #Creatine #Biohacking #HealthOptimization #FunctionalFitness #ExerciseScience #Science #MedicalResearch #EvidenceBased #Wellness #Health #HealthyLifestyle #Lifting #Gym #Squats #Deadlifts #LongevityScience #BrainFunction #Neuroplasticity #Learning #CognitiveHealth #VO2Max #Metabolism #Strength #PreventiveHealth #ExerciseMedicine #StayCurious
For additional nuances, all the references and early access to content like this, see the associated newsletter: open.substack.com/pub/staycuriousmetabolism/p/how-to-quietly-grow-your-brain-in?r=40ekz2&utm_campaign=post&utm_medium=web&showWelcomeOnShare=true
5-Amino-1-MQ Letter: staycuriousmetabolism.substack.com/p/the-metabolic-leak-that-might-be?r=40ekz2
Dihexa Letter: open.substack.com/pub/staycuriousmetabolism/p/dihexa-the-brain-boosting-peptide?r=40ekz2&utm_campaign=post&utm_medium=web&showWelcomeOnShare=true
If you want to try either 5-Amino-1-MQ or Dihexa, the company I personally use for these is Wingspan. I’ve vetted them and the meet all my criteria, including having high regulatory standards, cGMP certification, and they came recommended by a trusted colleague.
Try 5-Amino-1MQ → try.gotwingspan.com/norwitz5Amino1MQ
Try Dihexa → try.gotwingspan.com/norwitzDihexa
Discount code is “StayCurious”
Warning: These aren’t cheap products. I mention them for those who have the means and enjoy responsible self-experimentation.
Chapters
0:00 – Grow Your Brain in 30 Minutes Per Day?
2:03 – The Twin Study That Made Me Rethink Leg Day
6:23 – The BDNF-Irisin Axis
9:52 – How Muscles Maintain Healthy Blood Sugar
11:47 – Muscles, Brain, and Brain Blood Flow
12:13 – The Muscle-NAD-Brain Axis
13:17 – Practical Protocols
17:00 – 5-Amino-1-MQ: Plugging the Metabolic Leak
17:47 – Dihexa: 10,000,000 Times Stronger Than BDNF?
Description
Could your next leg workout do more than build muscle? In this video, we explore fascinating research showing that greater leg strength is associated with better cognitive aging, larger brain volume, and reduced cognitive decline—even among identical twins. You'll learn how your muscles act as endocrine organs, releasing signaling molecules that directly influence brain health, memory, metabolism, and resilience.
We'll unpack the science behind BDNF, irisin, insulin sensitivity, blood flow, and NAD+, then translate the research into practical training recommendations you can start using today. Finally, we'll discuss evidence-based supplements including creatine, 5-amino-1MQ, and Dihexa, and where they fit (and don't fit) alongside the fundamentals of exercise, sleep, and metabolic health.
For additional nuance, scientific references, and deeper dives into the mechanisms discussed in this video, check out the accompanying StayCurious letter linked above.
#BrainHealth #LegDay #Exercise #StrengthTraining #Longevity #HealthyAging #Neuroscience #Brain #Cognition #Memory #BDNF #Irisin #Muscle #MuscleHealth #Fitness #ResistanceTraining #Aging #Alzheimers #DementiaPrevention #MetabolicHealth #InsulinSensitivity #BloodSugar #NAD #Mitochondria #Creatine #Biohacking #HealthOptimization #FunctionalFitness #ExerciseScience #Science #MedicalResearch #EvidenceBased #Wellness #Health #HealthyLifestyle #Lifting #Gym #Squats #Deadlifts #LongevityScience #BrainFunction #Neuroplasticity #Learning #CognitiveHealth #VO2Max #Metabolism #Strength #PreventiveHealth #ExerciseMedicine #StayCurious
