Uploaded June 2017 | Updated September 2026, 2 weeks ago
If you like diceCT, you might want to try spiceCT! spiceCT – Selectively Perfusable Iodine-based Contrast-Enhanced CT. This is a new technique similar to diceCT in that it uses Lugol's iodine (I2KI) to enhance soft-tissue contrast in microCT, but it opts for perfusion rather than diffusion by directly delivering triiodide molecules to the tissues via vascular injection (i.e., perfusion). Specimens can be CT-scanned immediately, producing same-day results in a few hours rather than waiting days, weeks, or months for diffusion to take place, as in diceCT. Specimens do not require prior fixation in formalin and alcohol. These two cormorants (OUVC 10982 and OUVC 10985) were simply thawed, injected by Ruger Porter, PhD (assisted by Emily Caggiano), and then scanned immediately at the OUµCT, allowing data to be examined within four hours. The brain is not stained, because iodine does not pass the blood-brain barrier, although our team is working on protocols to defeat the BBB. For more content like this, check out our Facebook page (facebook.com/witmerlab)
If you like diceCT, you might want to try spiceCT! spiceCT – Selectively Perfusable Iodine-based Contrast-Enhanced CT. This is a new technique similar to diceCT in that it uses Lugol's iodine (I2KI) to enhance soft-tissue contrast in microCT, but it opts for perfusion rather than diffusion by directly delivering triiodide molecules to the tissues via vascular injection (i.e., perfusion). Specimens can be CT-scanned immediately, producing same-day results in a few hours rather than waiting days, weeks, or months for diffusion to take place, as in diceCT. Specimens do not require prior fixation in formalin and alcohol. These two cormorants (OUVC 10982 and OUVC 10985) were simply thawed, injected by Ruger Porter, PhD (assisted by Emily Caggiano), and then scanned immediately at the OUµCT, allowing data to be examined within four hours. The brain is not stained, because iodine does not pass the blood-brain barrier, although our team is working on protocols to defeat the BBB. For more content like this, check out our Facebook page (facebook.com/witmerlab)
