Uploaded June 2026 | Updated September 2026, 2 weeks ago
20-year follow-up of the WHI estrogen-only arm: 22% reduction in breast cancer incidence and 40% reduction in mortality. This is the part of the WHI story that did not make the 2002 headlines. Source: Chlebowski 2020, JAMA. Full episode linked in bio. #menopause #WHI #breastcancer #hormonereplacement #barbellmedicine
20-year follow-up of the WHI estrogen-only arm: 22% reduction in breast cancer incidence and 40% reduction in mortality. This is the part of the WHI story that did not make the 2002 headlines. Source: Chlebowski 2020, JAMA. Full episode linked in bio. #menopause #WHI #breastcancer #hormonereplacement #barbellmedicine
![They Removed the Tumor and the Weight Got Worse: Acquired Hypothalamic Obesity
The surgery works, the tumor is gone, the hormones are replaced, and the patient gains weight faster than before. This segment explains why: the operation touched the circuit that sets body weight. We walk the POMC brake and the AgRP accelerator, and set the record straight on leptin.
Timestamps:
00:00:00 The name: a tumor built from tooth tissue
00:00:18 Surgery, and what it costs
00:02:11 The new mystery: gaining weight faster than ever
00:08:09 The diagnosis: acquired hypothalamic obesity
00:13:45 How the brain sets weight: the brake and the accelerator
00:16:35 What about leptin?
Resources
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12. Guyenet SJ. The Hungry Brain: Outsmarting the Instincts That Make Us Overeat. Flatiron Books; 2017. They Removed the Tumor and the Weight Got Worse: Acquired Hypothalamic Obesity](https://i.ytimg.com/vi/bHZa0G-JDfk/mqdefault.jpg)









