The Company of Biologists | The shear force of tube elongation in lungs and kidneys @CompanyofBiologists | Uploaded May 2021 | Updated October 2024, 21 hours ago.
A recent Development paper from Dagmar Iber's group at ETH Zurich investigates how epithelial tubes in developing organs elongate. Such anisotropic growth is critical for tube function, yet the mechanisms underlying it have remained difficult to disentangle.
By live imaging cultured mouse bronchi and ureteric branches the researchers were able to discount a role for the surrounding mesenchyme, matrix turnover and FGF signalling. Rather, their data suggest that shear stress, derived from fluid flow inside the tubes, can give rise to biased elongation.
The paper comes with some beautiful movies which are collated above and which can be viewed in the context of the paper here:
journals.biologists.com/dev/article/148/9/dev194209/261770/The-biomechanical-basis-of-biased-epithelial-tube
You can also read an interview we ran with four of the papers authors - Lisa Conrad, Steve Runser, Roman Vetter and Dagmar Iber - here:
journals.biologists.com/dev/article/148/9/dev199638/261746/The-people-behind-the-papers-Lisa-Conrad-Steve
A recent Development paper from Dagmar Iber's group at ETH Zurich investigates how epithelial tubes in developing organs elongate. Such anisotropic growth is critical for tube function, yet the mechanisms underlying it have remained difficult to disentangle.
By live imaging cultured mouse bronchi and ureteric branches the researchers were able to discount a role for the surrounding mesenchyme, matrix turnover and FGF signalling. Rather, their data suggest that shear stress, derived from fluid flow inside the tubes, can give rise to biased elongation.
The paper comes with some beautiful movies which are collated above and which can be viewed in the context of the paper here:
journals.biologists.com/dev/article/148/9/dev194209/261770/The-biomechanical-basis-of-biased-epithelial-tube
You can also read an interview we ran with four of the papers authors - Lisa Conrad, Steve Runser, Roman Vetter and Dagmar Iber - here:
journals.biologists.com/dev/article/148/9/dev199638/261746/The-people-behind-the-papers-Lisa-Conrad-Steve
