Uploaded July 2021 | Updated September 2026, 2 days ago
Is RNA World Hypothesis true?
The RNA-world hypothesis is widely accepted by evolutionary biologists as a step to account for the development of the complexity seen in DNA based life.
We explore why this hypothesis is unviable given available data and observations.
===
Contents:
Is RNA-World Hypothesis Real?
Replication and Mutation
RNA-world Hypothesis
Catalysis for life!
RNA autocatalysis: Could RNA have just replicated itself?
RNA replication through enzymes?
Proteins
Ribosomes, Transcription, and Proteins!
The minimum genome?
How big can RNA be?
Kicking the can further?
RNA-world 4 Paradoxes
===
For those who prefer reading:
Article concerning the topic on: findingtruthchannel.com/courses/is-evolution-true-or-false/lessons/article-4-the-rna-world-hypothesis-is-paradoxical
===
References:
Molecular Biology of the Cell. 4th edition: ncbi.nlm.nih.gov/books/NBK26876
Autocatalytic Networks at the Basis of Life’s Origin and Organization: ncbi.nlm.nih.gov/pmc/articles/PMC6315399
(Def: merriam-webster.com/dictionary/catalysis
Read: Replication and Expression Strategies of Viruses: ncbi.nlm.nih.gov/pmc/articles/PMC7158166
Selection of an improved RNA polymerase ribozyme with superior extension and fidelity: rnajournal.cshlp.org/content/13/7/1017
Further reading with the following two papers, (DOI: 10.1261/rna.548807, DOI: 10.1126/science.1060786)
RNA Replicase, Read wiki here: en.wikipedia.org/wiki/RNA-dependent_RNA_polymerase
Read: Ribosomes - Definition, Structure, Size, Location and Function (microscopemaster.com): microscopemaster.com/ribosomes.html
Read about Ribosomes: en.wikipedia.org/wiki/Ribosome
Read: Systems Biology Perspectives on Minimal and Simpler Cells: ncbi.nlm.nih.gov/pmc/articles/PMC4187685
Systems Biology Perspectives on Minimal and Simpler Cells: ncbi.nlm.nih.gov/pmc/articles/PMC4187685
Read abstract: The evolution of genome compression and genomic novelty in RNA viruses: ncbi.nlm.nih.gov/pmc/articles/PMC1987338
Read article in nature mag: Discovery of the Giant Mimivirus: nature.com/scitable/topicpage/discovery-of-the-giant-mimivirus-14402410
Read: Genomics of Megavirus and the elusive fourth domain of Life: ncbi.nlm.nih.gov/pmc/articles/PMC3291303
Read it here in the abstract of this paper: The evolution of genome compression and genomic novelty in RNA viruses: ncbi.nlm.nih.gov/pmc/articles/PMC1987338
A Pre-RNA World Probably Predates the RNA World: ncbi.nlm.nih.gov/books/NBK26876
Did Gene Expression Co-evolve with Gene Replication? link.springer.com/chapter/10.1007%2F978-3-319-95954-2_16
===
Videos used in the session for educational purposes:
From DNA to protein - 3D: youtu.be/gG7uCskUOrA
Six Microseconds of Protein Folding: youtu.be/sD6vyfTtE4U
===
#RNAWorld #EvolutionCourse
Remember to send your questions for the Saturday livestream.
Watch and share with loved ones:
youtu.be/uarchKbVtkw
Is RNA World Hypothesis true?
The RNA-world hypothesis is widely accepted by evolutionary biologists as a step to account for the development of the complexity seen in DNA based life.
We explore why this hypothesis is unviable given available data and observations.
===
Contents:
Is RNA-World Hypothesis Real?
Replication and Mutation
RNA-world Hypothesis
Catalysis for life!
RNA autocatalysis: Could RNA have just replicated itself?
RNA replication through enzymes?
Proteins
Ribosomes, Transcription, and Proteins!
The minimum genome?
How big can RNA be?
Kicking the can further?
RNA-world 4 Paradoxes
===
For those who prefer reading:
Article concerning the topic on: findingtruthchannel.com/courses/is-evolution-true-or-false/lessons/article-4-the-rna-world-hypothesis-is-paradoxical
===
References:
Molecular Biology of the Cell. 4th edition: ncbi.nlm.nih.gov/books/NBK26876
Autocatalytic Networks at the Basis of Life’s Origin and Organization: ncbi.nlm.nih.gov/pmc/articles/PMC6315399
(Def: merriam-webster.com/dictionary/catalysis
Read: Replication and Expression Strategies of Viruses: ncbi.nlm.nih.gov/pmc/articles/PMC7158166
Selection of an improved RNA polymerase ribozyme with superior extension and fidelity: rnajournal.cshlp.org/content/13/7/1017
Further reading with the following two papers, (DOI: 10.1261/rna.548807, DOI: 10.1126/science.1060786)
RNA Replicase, Read wiki here: en.wikipedia.org/wiki/RNA-dependent_RNA_polymerase
Read: Ribosomes - Definition, Structure, Size, Location and Function (microscopemaster.com): microscopemaster.com/ribosomes.html
Read about Ribosomes: en.wikipedia.org/wiki/Ribosome
Read: Systems Biology Perspectives on Minimal and Simpler Cells: ncbi.nlm.nih.gov/pmc/articles/PMC4187685
Systems Biology Perspectives on Minimal and Simpler Cells: ncbi.nlm.nih.gov/pmc/articles/PMC4187685
Read abstract: The evolution of genome compression and genomic novelty in RNA viruses: ncbi.nlm.nih.gov/pmc/articles/PMC1987338
Read article in nature mag: Discovery of the Giant Mimivirus: nature.com/scitable/topicpage/discovery-of-the-giant-mimivirus-14402410
Read: Genomics of Megavirus and the elusive fourth domain of Life: ncbi.nlm.nih.gov/pmc/articles/PMC3291303
Read it here in the abstract of this paper: The evolution of genome compression and genomic novelty in RNA viruses: ncbi.nlm.nih.gov/pmc/articles/PMC1987338
A Pre-RNA World Probably Predates the RNA World: ncbi.nlm.nih.gov/books/NBK26876
Did Gene Expression Co-evolve with Gene Replication? link.springer.com/chapter/10.1007%2F978-3-319-95954-2_16
===
Videos used in the session for educational purposes:
From DNA to protein - 3D: youtu.be/gG7uCskUOrA
Six Microseconds of Protein Folding: youtu.be/sD6vyfTtE4U
===
#RNAWorld #EvolutionCourse
Remember to send your questions for the Saturday livestream.
Watch and share with loved ones:
youtu.be/uarchKbVtkw
