Uploaded May 2022 | Updated September 2026, 1 day ago

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High homocysteine levels are associated with cardiovascular disease and dementia. A series of studies have shown that the relationship with cardiovascular disease is not causal [1,2]. However, yet another series of randomized controlled trials have shown that reducing homocysteine levels reduces brain atrophy and cognitive decline [3,4,5], as well as risk of stroke [6] and symptom severity in schizophrenia [7,8]. Yet other studies suggest still other benefits for psychiatric disorders such as bipolar disorder [9]. This podcast explores the risks and benefits of homocysteine reduction by the use of three vitamins: B12, B6, and folate, as well as what might be the recommended dose for this purpose [10].

References (PMIDs):
[1] 16450017
[2] 16531614
[3] 20838622
[4] 23690582
[5] 25877495
[6] 19228852
[7] 23467813
[8] 16412989
[9] 35386526
[10] 31677936

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