Uploaded September 2024 | Updated September 2026, 14 hours ago
When Sarah Robb O’Hagan began leading the turnaround of the $5 billion global Gatorade business amid a global recession, she was also preparing to give birth to her third child. Largely skipping her maternity leave, the combination of extreme hours and late-night childcare led her to experience an extreme and painful “burnout” that changed her perspective and her approach to work life forever.
Years later — taking on the role of CEO at EXOS, the human performance company, at the start of the global pandemic — she decided that a successful business turnaround while burning people out was not an option. As a result, she partnered with the performance science experts on her team, as well as some of the best organizational psychologists in the world to design and implement a far more sustainable and enjoyable way of getting business results while working under immense pressure.
In this talk, Sarah outlines:
Why high performance and productivity do not have to happen at the expense of human wellbeing — with proprietary research and data to prove the case
How to balance the load of intense work and pressure, with periods of intentional recovery to optimize the human system for higher performance
How to design your workplace with simple hacks to improve the wellbeing and performance of your team so that you can attract and retain the best talent
How to understand the connection between your mind and your body as it relates to overcoming feelings of intense stress and exhaustion
The magical force multiplier of getting into “flow state” to drive greater productivity for the team, and fulfillment for individuals
Sarah Robb O’Hagan is a high-energy combination of disruptive business leader, fitness fanatic, and cheerleading mom. She's been named among Fast Company’s “Most Creative People in Business.” and Forbes "Most Powerful Women in Sports". She is currently CEO of EXOS the Human Performance company where she is transforming the business through digital solutions. Prior to this she led the reinvention and turnaround of the $5Bn Gatorade business as its global president, before leading the digital transformation of Equinox Fitness Clubs as president. Sarah has also held leadership positions at Nike and Virgin and currently sits on the boards of Jet Blue, and previously Strava. In 2017, her first book was published by Harper Collins - ExtremeYou - Step Up. Stand Out. Kick Ass. Repeat. Sarah is a sought-after expert on business innovation, and inspiring human performance and is a passionate advocate for getting young women into sports and physical activity to increase their leadership potential. Sarah is a trustee emeritus of the Women's Sports Foundation, A Henry Crown Fellow of the Aspen Institute, and as a proud "Ameri-Kiwi" is an active member of the KEA World Class New Zealand Network.
This lecture is part of the IHMC Evening Lecture series.
ihmc.us/life/evening_lectures
When Sarah Robb O’Hagan began leading the turnaround of the $5 billion global Gatorade business amid a global recession, she was also preparing to give birth to her third child. Largely skipping her maternity leave, the combination of extreme hours and late-night childcare led her to experience an extreme and painful “burnout” that changed her perspective and her approach to work life forever.
Years later — taking on the role of CEO at EXOS, the human performance company, at the start of the global pandemic — she decided that a successful business turnaround while burning people out was not an option. As a result, she partnered with the performance science experts on her team, as well as some of the best organizational psychologists in the world to design and implement a far more sustainable and enjoyable way of getting business results while working under immense pressure.
In this talk, Sarah outlines:
Why high performance and productivity do not have to happen at the expense of human wellbeing — with proprietary research and data to prove the case
How to balance the load of intense work and pressure, with periods of intentional recovery to optimize the human system for higher performance
How to design your workplace with simple hacks to improve the wellbeing and performance of your team so that you can attract and retain the best talent
How to understand the connection between your mind and your body as it relates to overcoming feelings of intense stress and exhaustion
The magical force multiplier of getting into “flow state” to drive greater productivity for the team, and fulfillment for individuals
Sarah Robb O’Hagan is a high-energy combination of disruptive business leader, fitness fanatic, and cheerleading mom. She's been named among Fast Company’s “Most Creative People in Business.” and Forbes "Most Powerful Women in Sports". She is currently CEO of EXOS the Human Performance company where she is transforming the business through digital solutions. Prior to this she led the reinvention and turnaround of the $5Bn Gatorade business as its global president, before leading the digital transformation of Equinox Fitness Clubs as president. Sarah has also held leadership positions at Nike and Virgin and currently sits on the boards of Jet Blue, and previously Strava. In 2017, her first book was published by Harper Collins - ExtremeYou - Step Up. Stand Out. Kick Ass. Repeat. Sarah is a sought-after expert on business innovation, and inspiring human performance and is a passionate advocate for getting young women into sports and physical activity to increase their leadership potential. Sarah is a trustee emeritus of the Women's Sports Foundation, A Henry Crown Fellow of the Aspen Institute, and as a proud "Ameri-Kiwi" is an active member of the KEA World Class New Zealand Network.
This lecture is part of the IHMC Evening Lecture series.
ihmc.us/life/evening_lectures








![Episode 192: Ken and Dawn weigh in on ChatGPT, ketamine, urolithin-A, rapamycin, and more in wide...
ChatGPT has been in the news a lot lately and, as a result, quite a few STEM-Talk listeners have tossed us questions about the reliability and limitations of generative-artificial intelligence chatbots as well as large-language models more broadly. Ken and Dawn tackle this question and a number of others in today’s Ask Me Anything episode.
We have listeners wondering why astronauts train in underwater conditions for spacewalks; icebreakers in antarctica; the value of supplementing with urolithin-A; and the effectiveness of L-citrulline in helping aging blood vessels.
Ken also weights in on questions related to lithium deficiency and the onset of Alzheimer’s disease; a study that found mTOR activation may not be necessary for ketamine’s beneficial effects in the context of depression; and a paper that demonstrated short-term mTOR inhibition by rapamycin improved cardiac and endothelial function in older men.
Show notes:
[00:02:49] Ken opens our AMA with a listener question for Dawn, which asks why, despite the differences between diving and zero-gravity environments, why do astronauts train in underwater conditions for spacewalks. The listener goes on to mention an article they read about NASA’s neutral buoyancy lab in Houston, which contains a partial replica of the International Space Station.
[00:07:42] A listener asks Ken if he is still optimistic about the value of supplementing with urolithin-A, and if so, is there a brand he recommends. Ken mentions episodes 118, with Julie Anderson (https://www.ihmc.us/stemtalk/episode-118/) , and 173, with Anurag Singh. (https://www.ihmc.us/stemtalk/episode-173/) Ken also discusses a paper titled “Effect of the mitophagy inducer urolithin A on age related immune decline, a randomized placebo-controlled trial” (https://www.nature.com/articles/s43587-025-00996-x) co-authored by Anurag. Ken also mentions clinical research supporting the urolithin-A supplement Mitopure. (https://www.timeline.com/mitopure)
[00:10:53] A listener asks Ken about a paper titled “Short-term mTOR inhibition by rapamycin improves cardiac and endothelial function in older men: a proof-of-concept pilot study.” (https://link.springer.com/article/10.1007/s11357-025-01855-8)
[00:14:29] Ken discusses a 2020 paper from a research group at Yale, (https://pubmed.ncbi.nlm.nih.gov/32092760/) which suggested that mTOR activation may not be necessary for ketamine’s beneficial effects in the context of depression. The paper also reported that m-TOR suppression via rapamycin might prolong ketamine’s antidepressant effects.
[00:18:47] A research scientist formerly working in Antarctica asks Ken about Russia’s dominance in the realm of ice breakers.
[00:23:55] A listener mentions that for some people, when they used ChatGPT to ask about the assassination of political commentator Charlie Kirk, ChatGPT sometimes responded by denying the assassination occurred. The listener asks Ken about the credibility and reliability of generative AI and large-language models.
[00:28:49] Several listeners have submitted questions for Ken regarding a paper published in Nature in August of last year titled “Lithium deficiency in the onset of Alzheimer’s disease.” (https://www.nature.com/articles/s41586-025-09335-x) Ken gives his thoughts on this paper.
[00:31:56] For our final question this AMA, a listener asks Ken about the arginine paradox, which regards L-arginine, which is used by the body to make nitric oxide, which is necessary to relax and maintain flexibility of blood vessels. However, several papers have reported that supplementation of arginine does not reliably improve aging blood vessels. In contrast, recent research suggests that L-citrulline might be more effective. The listeners sent questions asking about the possible effects of citrulline in vascular health and aging.
In his answer, Ken cites the following papers:
— Administration of L-arginine plus L-citrulline or L-citrulline alone successfully retarded endothelial senescence (https://journals.plos.org/plosone/article/file?id=10.1371%2Fjournal.pone.0192252&type=printable&utm_source=chatgpt.com) .
— Effects of L-Citrulline Supplementation on Endothelial Function, Arterial Stiffness, and Blood Glucose Level in the Fasted and Acute Hyperglycemic States in Middle-Aged and Older Adults with Type 2 Diabetes. (https://www.mdpi.com/2072-6643/17/23/3739?utm_source=chatgpt.com)
— Citrulline Supplementation Improves Microvascular Function and Muscle Strength in Middle-Aged and Older Adults with Type 2 Diabetes. (https://www.mdpi.com/2072-6643/17/17/2790?utm_source=chatgpt.com)
— Effects of L-citrulline supplementation and watermelon intake on arterial stiffness and endothelial function in middle-aged and older adults: a systematic review and meta-analysis of randomized controlled trials (https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2025.1632952/full?utm_source=chatgpt.com) .
— Citrulli... Episode 192: Ken and Dawn weigh in on ChatGPT, ketamine, urolithin-A, rapamycin, and more in wide...](https://i.ytimg.com/vi/ltF9e7TKlc8/mqdefault.jpg)

