Uploaded April 2025 | Updated September 2026, 20 hours ago
Establishing a fixed base on the Moon at a high southern latitude but off-polar site, with a versatile mobility system for surface and point-to-point transportation, would far more optimally serve the United States' science, exploration, and strategic interests on the Moon than the series of sortie missions to the lunar south polar regions currently planned in the Artemis program. In an ongoing search for candidate sites to establish a lunar base, Clavius crater is emerging as an intriguing option. It offers unique and exciting geology spanning almost the entire history of the Moon, and relatively easy access to many other sites of interest including the lunar South Pole. Beyond Clavius' exceptional inherent value, a "Clavius Base", first depicted in the movie "2001: A Space Odyssey", could also serve as a public engaging case of reality meeting fiction.
Dr. Pascal Lee is a planetary scientist with the SETI Institute, the Mars Institute, and NASA Ames Research Center in Mountain View, California. He is also professor of planetary sciences at Kepler Space University.
Pascal studied physics at the University of Paris-Sorbonne and holds an M.E. in engineering geology and geophysics from Polytech-Sorbonne. He went on to earn a MS and PhD in astronomy and space sciences from Cornell University where he was Carl Sagan’s last T.A. His research focuses on the Moon and Mars, in particular the history of water and ice, and planning the future human exploration of these worlds. Earlier this year, he and his student, Sourabh Shubham, announced the discovery of a previously unrecognized giant volcano on Mars, the Noctis Volcano.
Pascal has led over 30 expeditions to the Arctic and Antarctica to study Mars by comparison with the Earth. He wintered-over for 402 days at the French Antarctic base, Dumont d'Urville, and also led the Northwest Passage Drive Expedition – a record-setting vehicular drive across the Arctic along the fabled Northwest Passage, and now the subject of the award-winning motion picture documentary film, Passage To Mars.
Dr Lee is currently a member of the US National Academies’ steering committee on “A Science Strategy for the Human Exploration of Mars”. He is a recipient of the United States Antarctica Service Medal, the National Space Society Space Pioneer Award for Science and Engineering, the Space Frontier Foundation’s Vision to Reality Award, and the Sagan Prize for the Popularization of Science.
In his free time, Pascal likes to be walked by his dog Apollo, fly, and paint. He is an FAA-certified helicopter commercial pilot and flight instructor. His oil paintings on Mars exploration and spacetime travel are in collections worldwide.
This lecture is part of the IHMC Evening Lecture series.
ihmc.us/life/evening_lectures
Establishing a fixed base on the Moon at a high southern latitude but off-polar site, with a versatile mobility system for surface and point-to-point transportation, would far more optimally serve the United States' science, exploration, and strategic interests on the Moon than the series of sortie missions to the lunar south polar regions currently planned in the Artemis program. In an ongoing search for candidate sites to establish a lunar base, Clavius crater is emerging as an intriguing option. It offers unique and exciting geology spanning almost the entire history of the Moon, and relatively easy access to many other sites of interest including the lunar South Pole. Beyond Clavius' exceptional inherent value, a "Clavius Base", first depicted in the movie "2001: A Space Odyssey", could also serve as a public engaging case of reality meeting fiction.
Dr. Pascal Lee is a planetary scientist with the SETI Institute, the Mars Institute, and NASA Ames Research Center in Mountain View, California. He is also professor of planetary sciences at Kepler Space University.
Pascal studied physics at the University of Paris-Sorbonne and holds an M.E. in engineering geology and geophysics from Polytech-Sorbonne. He went on to earn a MS and PhD in astronomy and space sciences from Cornell University where he was Carl Sagan’s last T.A. His research focuses on the Moon and Mars, in particular the history of water and ice, and planning the future human exploration of these worlds. Earlier this year, he and his student, Sourabh Shubham, announced the discovery of a previously unrecognized giant volcano on Mars, the Noctis Volcano.
Pascal has led over 30 expeditions to the Arctic and Antarctica to study Mars by comparison with the Earth. He wintered-over for 402 days at the French Antarctic base, Dumont d'Urville, and also led the Northwest Passage Drive Expedition – a record-setting vehicular drive across the Arctic along the fabled Northwest Passage, and now the subject of the award-winning motion picture documentary film, Passage To Mars.
Dr Lee is currently a member of the US National Academies’ steering committee on “A Science Strategy for the Human Exploration of Mars”. He is a recipient of the United States Antarctica Service Medal, the National Space Society Space Pioneer Award for Science and Engineering, the Space Frontier Foundation’s Vision to Reality Award, and the Sagan Prize for the Popularization of Science.
In his free time, Pascal likes to be walked by his dog Apollo, fly, and paint. He is an FAA-certified helicopter commercial pilot and flight instructor. His oil paintings on Mars exploration and spacetime travel are in collections worldwide.
This lecture is part of the IHMC Evening Lecture series.
ihmc.us/life/evening_lectures


![Episode 192: Ken and Dawn weigh in on ChatGPT, ketamine, urolithin-A, rapamycin, and more in wide...
ChatGPT has been in the news a lot lately and, as a result, quite a few STEM-Talk listeners have tossed us questions about the reliability and limitations of generative-artificial intelligence chatbots as well as large-language models more broadly. Ken and Dawn tackle this question and a number of others in today’s Ask Me Anything episode.
We have listeners wondering why astronauts train in underwater conditions for spacewalks; icebreakers in antarctica; the value of supplementing with urolithin-A; and the effectiveness of L-citrulline in helping aging blood vessels.
Ken also weights in on questions related to lithium deficiency and the onset of Alzheimer’s disease; a study that found mTOR activation may not be necessary for ketamine’s beneficial effects in the context of depression; and a paper that demonstrated short-term mTOR inhibition by rapamycin improved cardiac and endothelial function in older men.
Show notes:
[00:02:49] Ken opens our AMA with a listener question for Dawn, which asks why, despite the differences between diving and zero-gravity environments, why do astronauts train in underwater conditions for spacewalks. The listener goes on to mention an article they read about NASA’s neutral buoyancy lab in Houston, which contains a partial replica of the International Space Station.
[00:07:42] A listener asks Ken if he is still optimistic about the value of supplementing with urolithin-A, and if so, is there a brand he recommends. Ken mentions episodes 118, with Julie Anderson (https://www.ihmc.us/stemtalk/episode-118/) , and 173, with Anurag Singh. (https://www.ihmc.us/stemtalk/episode-173/) Ken also discusses a paper titled “Effect of the mitophagy inducer urolithin A on age related immune decline, a randomized placebo-controlled trial” (https://www.nature.com/articles/s43587-025-00996-x) co-authored by Anurag. Ken also mentions clinical research supporting the urolithin-A supplement Mitopure. (https://www.timeline.com/mitopure)
[00:10:53] A listener asks Ken about a paper titled “Short-term mTOR inhibition by rapamycin improves cardiac and endothelial function in older men: a proof-of-concept pilot study.” (https://link.springer.com/article/10.1007/s11357-025-01855-8)
[00:14:29] Ken discusses a 2020 paper from a research group at Yale, (https://pubmed.ncbi.nlm.nih.gov/32092760/) which suggested that mTOR activation may not be necessary for ketamine’s beneficial effects in the context of depression. The paper also reported that m-TOR suppression via rapamycin might prolong ketamine’s antidepressant effects.
[00:18:47] A research scientist formerly working in Antarctica asks Ken about Russia’s dominance in the realm of ice breakers.
[00:23:55] A listener mentions that for some people, when they used ChatGPT to ask about the assassination of political commentator Charlie Kirk, ChatGPT sometimes responded by denying the assassination occurred. The listener asks Ken about the credibility and reliability of generative AI and large-language models.
[00:28:49] Several listeners have submitted questions for Ken regarding a paper published in Nature in August of last year titled “Lithium deficiency in the onset of Alzheimer’s disease.” (https://www.nature.com/articles/s41586-025-09335-x) Ken gives his thoughts on this paper.
[00:31:56] For our final question this AMA, a listener asks Ken about the arginine paradox, which regards L-arginine, which is used by the body to make nitric oxide, which is necessary to relax and maintain flexibility of blood vessels. However, several papers have reported that supplementation of arginine does not reliably improve aging blood vessels. In contrast, recent research suggests that L-citrulline might be more effective. The listeners sent questions asking about the possible effects of citrulline in vascular health and aging.
In his answer, Ken cites the following papers:
— Administration of L-arginine plus L-citrulline or L-citrulline alone successfully retarded endothelial senescence (https://journals.plos.org/plosone/article/file?id=10.1371%2Fjournal.pone.0192252&type=printable&utm_source=chatgpt.com) .
— Effects of L-Citrulline Supplementation on Endothelial Function, Arterial Stiffness, and Blood Glucose Level in the Fasted and Acute Hyperglycemic States in Middle-Aged and Older Adults with Type 2 Diabetes. (https://www.mdpi.com/2072-6643/17/23/3739?utm_source=chatgpt.com)
— Citrulline Supplementation Improves Microvascular Function and Muscle Strength in Middle-Aged and Older Adults with Type 2 Diabetes. (https://www.mdpi.com/2072-6643/17/17/2790?utm_source=chatgpt.com)
— Effects of L-citrulline supplementation and watermelon intake on arterial stiffness and endothelial function in middle-aged and older adults: a systematic review and meta-analysis of randomized controlled trials (https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2025.1632952/full?utm_source=chatgpt.com) .
— Citrulli... Episode 192: Ken and Dawn weigh in on ChatGPT, ketamine, urolithin-A, rapamycin, and more in wide...](https://i.ytimg.com/vi/ltF9e7TKlc8/mqdefault.jpg)







