RCSBProteinDataBank | Penicillin Binding Protein: Binding Ampicillin @RCSBProteinDataBank | Uploaded February 2018 | Updated October 2024, 4 days ago.
In this video you can see how the enzyme penicillin binding protein is inactivated by the antibiotic Ampicillin binding covalently in the active site.

This video was created as a learning resource for the 2018 RCSB PDB Video Challenge for High School Students "Mechanisms of Bacterial Resistance to Beta-lactam Antibiotics".

To find out more about the challenge and to participate visit PDB-101 (pdb101.rcsb.org/events/video-challenge/the-challenge).