Uploaded January 2025 | Updated September 2026, 2 days ago
Dr. Hubert Pausch 's presentation focuses on the use of pan-genome wide association testing to identify structural variants linked to traits in cattle and their wild relatives. He describes the evolutionary divergence of the two main cattle subspecies, Bos Taurus Taurus and Bos Taurus Indicus, and their different adaptations. He explains that by using advanced sequencing technologies, such as PacBio HiFi reads, they were able to generate near-perfect genome assemblies with high coverage. These advancements have allowed researchers to build pan-genomes, revealing structural variations that are critical for trait association studies.
Examples included a 17 kbKB insertion associated with dietary adaptation in wild relatives and a gene deletion linked to low fat content in bison meat. Additionally, a repeat element insertion was found to be that was linked to pigmentation traits. Dr. Pausch concluded by emphasizing the importance of HiFi reads in generating accurate genomes and the crucial role of structural variants in phenotypic diversity.
🔔 Subscribe to our channel youtube.com/channel/UC2y78sjVOumGc2da1tN629g?sub_confirmation=1
Learn more about PacBio at pacb.com
Legal & Trademarks: Visit pacb.com/legal-and-trademarks
Dr. Hubert Pausch 's presentation focuses on the use of pan-genome wide association testing to identify structural variants linked to traits in cattle and their wild relatives. He describes the evolutionary divergence of the two main cattle subspecies, Bos Taurus Taurus and Bos Taurus Indicus, and their different adaptations. He explains that by using advanced sequencing technologies, such as PacBio HiFi reads, they were able to generate near-perfect genome assemblies with high coverage. These advancements have allowed researchers to build pan-genomes, revealing structural variations that are critical for trait association studies.
Examples included a 17 kbKB insertion associated with dietary adaptation in wild relatives and a gene deletion linked to low fat content in bison meat. Additionally, a repeat element insertion was found to be that was linked to pigmentation traits. Dr. Pausch concluded by emphasizing the importance of HiFi reads in generating accurate genomes and the crucial role of structural variants in phenotypic diversity.
🔔 Subscribe to our channel youtube.com/channel/UC2y78sjVOumGc2da1tN629g?sub_confirmation=1
Learn more about PacBio at pacb.com
Legal & Trademarks: Visit pacb.com/legal-and-trademarks
