Uploaded April 2026 | Updated September 2026, 1 week ago

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For a written breakdown, early access to content like this, and extra nuances, see the associated StayCurious Metabolism newsletter: staycuriousmetabolism.substack.com/p/this-new-study-changed-my-mind-on?r=40ekz2

For years, it’s been widely assumed that GLP-1 weight loss drugs cause unusually high muscle loss. But new data suggest DEXA scans may be lumping together very different forms of “lean mass,” including liver tissue and stored muscle substrate, not just functional muscle. In a proof-of-principle human trial, muscle size decreased, but upper- and lower-body strength was fully maintained. For the full mechanisms, limitations, and nuance, watch the long-form breakdown linked above.

#GLP1 #LeanMass #MuscleHealth #WeightLossScience #DEXA #MetabolicHealth #StayCurious