Uploaded March 2026 | Updated September 2026, 1 week ago
For the references, extra nuance and access to more deep-dives, join the StayCurious Metabolism community: staycuriousmetabolism.substack.com/p/this-drug-raises-ldl-cholesteroland?r=40ekz2
For so much more on heart health, just out our heart health library, HERE: staycuriousmetabolism.substack.com/p/hearthealth
What if a medication can raise LDL cholesterol yet still reduce cardiovascular deaths? In this video, I walk through the science behind SGLT2 inhibitors. We will discuss a landmark trial published in The New England Journal of Medicine, dive deeper into the mechanism using new animal and human data published in Nature Aging. This isn’t a video about a simple drug, but a case study in how cholesterol narratives are built.
Chapters
0:00 – A Paradox: A Drug That Raises LDL but Saves Lives
1:32 – Roadmap: Cholesterol Narratives, Clinical Trials, and Mechanisms
2:12 – Chapter 1: The Pattern. LDL is “Bad” Cholesterol
5:45 – Chapter 2: SGLT2 Inhibitor and a Major Clinical Trial
10:18 – Chapter 3: Mechanisms and Mysteries! How They Work
14:12 – Proof People Want Nuance…
#CardiovascularHealth #LDL #Cholesterol #ApoB #HDL #SGLT2 #Diabetes #HeartDiseaseResearch #Longevity #AMPK #RCT #KetogenicDiet #FastingScience #MetabolicHealth #Atherosclerosis #CardiovascularDisease #InsulinResistance #Obesity #Healthspan #EvidenceBasedMedicine #ClinicalTrials #MedicalEducation #PreventiveCardiology #SystemsBiology #StayCurious #Metabolism
For the references, extra nuance and access to more deep-dives, join the StayCurious Metabolism community: staycuriousmetabolism.substack.com/p/this-drug-raises-ldl-cholesteroland?r=40ekz2
For so much more on heart health, just out our heart health library, HERE: staycuriousmetabolism.substack.com/p/hearthealth
What if a medication can raise LDL cholesterol yet still reduce cardiovascular deaths? In this video, I walk through the science behind SGLT2 inhibitors. We will discuss a landmark trial published in The New England Journal of Medicine, dive deeper into the mechanism using new animal and human data published in Nature Aging. This isn’t a video about a simple drug, but a case study in how cholesterol narratives are built.
Chapters
0:00 – A Paradox: A Drug That Raises LDL but Saves Lives
1:32 – Roadmap: Cholesterol Narratives, Clinical Trials, and Mechanisms
2:12 – Chapter 1: The Pattern. LDL is “Bad” Cholesterol
5:45 – Chapter 2: SGLT2 Inhibitor and a Major Clinical Trial
10:18 – Chapter 3: Mechanisms and Mysteries! How They Work
14:12 – Proof People Want Nuance…
#CardiovascularHealth #LDL #Cholesterol #ApoB #HDL #SGLT2 #Diabetes #HeartDiseaseResearch #Longevity #AMPK #RCT #KetogenicDiet #FastingScience #MetabolicHealth #Atherosclerosis #CardiovascularDisease #InsulinResistance #Obesity #Healthspan #EvidenceBasedMedicine #ClinicalTrials #MedicalEducation #PreventiveCardiology #SystemsBiology #StayCurious #Metabolism
